Details of the Target

General Information of Target

Target ID LDTP17551
Target Name Ankyrin and armadillo repeat-containing protein (ANKAR)
Gene Name ANKAR
Gene ID 150709
Synonyms
Ankyrin and armadillo repeat-containing protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAMVSAMSWVLYLWISACAMLLCHGSLQHTFQQHHLHRPEGGTCEVIAAHRCCNKNRIEE
RSQTVKCSCLPGKVAGTTRNRPSCVDASIVIGKWWCEMEPCLEGEECKTLPDNSGWMCAT
GNKIKTTRIHPRT
Target Bioclass
Other
Subcellular location
Membrane
Uniprot ID
Q7Z5J8
Ensemble ID
ENST00000313581.4
HGNC ID
HGNC:26350

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A2058 SNV: p.D364N .
FTC133 Deletion: p.L1038YfsTer4 .
HCT15 SNV: p.A741V .
HT115 SNV: p.S949L .
JHH7 Deletion: p.I607LfsTer20 .
KATOIII SNV: p.R602I .
NCIH358 SNV: p.A505P .
OVK18 SNV: p.W735Ter .
OVTOKO SNV: p.R491T .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IA-alkyne
 Probe Info  		N.A.  LDD0174  [1]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [2]

References

1 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
2 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853