Details of the Target

General Information of Target

Target ID LDTP17541
Target Name SUZ domain-containing protein 1 (SZRD1)
Gene Name SZRD1
Gene ID 26099
Synonyms
C1orf144; SUZ domain-containing protein 1; Putative MAPK-activating protein PM18/PM20/PM22
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEENPTLESEAWGSSRGWLAPREARGAPCSSPGPSLSSVLNELPSAATLRYRDPGVLPWG
ALEEEEEDGGRSRKAFTEVTQTELQDPHPSRELPWPMQARRAHRQRNASRDQVVYGSGTK
TDRWARLLRRSKEKTKEGLRSLQPWAWTLKRIGGQFGAGTESYFSLLRFLLLLNVLASVL
MACMTLLPTWLGGAPPGPPGPDISSPCGSYNPHSQGLVTFATQLFNLLSGEGYLEWSPLF
YGFYPPRPRLAVTYLCWAFAVGLICLLLILHRSVSGLKQTLLAESEALTSYSHRVFSAWD
FGLCGDVHVRLRQRIILYELKVELEETVVRRQAAVRTLGQQARVWLVRVLLNLLVVALLG
AAFYGVYWATGCTVELQEMPLVQELPLLKLGVNYLPSIFIAGVNFVLPPVFKLIAPLEGY
TRSRQIVFILLRTVFLRLASLVVLLFSLWNQITCGGDSEAEDCKTCGYNYKQLPCWETVL
GQEMYKLLLFDLLTVLAVALLIQFPRKLLCGLCPGALGRLAGTQEFQVPDEVLGLIYAQT
VVWVGSFFCPLLPLLNTVKFLLLFYLKKLTLFSTCSPAARTFRASAANFFFPLVLLLGLA
ISSVPLLYSIFLIPPSKLCGPFRGQSSIWAQIPESISSLPETTQNFLFFLGTQAFAVPLL
LISSILMAYTVALANSYGRLISELKRQRQTEAQNKVFLARRAVALTSTKPAL
Target Bioclass
Other
Family
SZRD1 family
Uniprot ID
Q7Z422
Ensemble ID
ENST00000401088.9
HGNC ID
HGNC:30232

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CCK81 SNV: p.E24K .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K32(4.53)  LDD0277  [1]
Probe 1
 Probe Info  		Y95(17.90)  LDD3495  [2]
HHS-475
 Probe Info  		Y95(0.19)  LDD0264  [3]
IA-alkyne
 Probe Info  		C464(0.00); C173(0.00); C82(0.00)  LDD0161  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0116  HHS-0101 DM93 Y95(0.19)  LDD0264  [3]
 LDCM0117  HHS-0201 DM93 Y95(0.58)  LDD0265  [3]
 LDCM0118  HHS-0301 DM93 Y95(0.12)  LDD0266  [3]
 LDCM0119  HHS-0401 DM93 Y95(0.72)  LDD0267  [3]
 LDCM0120  HHS-0701 DM93 Y95(0.88)  LDD0268  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Serine-threonine kinase receptor-associated protein (STRAP) WD repeat STRAP family Q9Y3F4

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
3 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
4 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060