Details of the Target

General Information of Target

Target ID LDTP17539
Target Name Transmembrane channel-like protein 7 (TMC7)
Gene Name TMC7
Gene ID 79905
Synonyms
Transmembrane channel-like protein 7
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPHLLVTFRDVAIDFSQEEWECLDPAQRDLYRDVMLENYSNLISLDLESSCVTKKLSPEK
EIYEMESLQWENMGKRINHHLQYNGLGDNMECKGNLEGQEASQEGLYMCVKITCEEKATE
SHSTSSTFHRIIPTKEKLYKCKECRQGFSYLSCLIQHEENHNIEKCSEVKKHRNTFSKKP
SYIQHQRIQTGEKPYECMECGKAFGRTSDLIQHQKIHTNEKPYQCNACGKAFIRGSQLTE
HQRVHTGEKPYECKKCGKAFSYCSQYTLHQRIHSGEKPYECKDCGKAFILGSQLTYHQRI
HSGEKPYECKECGKAFILGSHLTYHQRVHTGEKPYICKECGKAFLCASQLNEHQRIHTGE
KPYECKECGKTFFRGSQLTYHLRVHSGERPYKCKECGKAFISNSNLIQHQRIHTGEKPYK
CKECGKAFICGKQLSEHQRIHTGEKPFECKECGKAFIRVAYLTQHEKIHGEKHYECKECG
KTFVRATQLTYHQRIHTGEKPYKCKECDKAFIYGSQLSEHQRIHRGEKPYECKQCGKAFI
RGSHLTEHLRTHTGEKPYECKECGRAFSRGSELTLHQRIHTGEKPYTCVQCGKDFRCPSQ
LTQHTRLHN
Target Bioclass
Transporter and channel
Family
TMC family
Subcellular location
Membrane
Function Probable ion channel.
Uniprot ID
Q7Z402
Ensemble ID
ENST00000304381.10
HGNC ID
HGNC:23000

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A549 SNV: p.Y577C .
CCK81 Deletion: p.Q535SfsTer13 .
HS936T SNV: p.G290E .
KYSE180 SNV: p.L67R .
MFE319 SNV: p.M721K .
MOLT4 SNV: p.A684V .
REH SNV: p.A82T .
UACC62 SNV: p.V669A .
WM2664 Insertion: p.M423NfsTer10 .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
YN-1
 Probe Info  		N.A.  LDD0447  [1]

References

1 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.