Details of the Target

General Information of Target

Target ID LDTP17528
Target Name Monocarboxylate transporter 14 (SLC16A14)
Gene Name SLC16A14
Gene ID 151473
Synonyms
MCT14; Monocarboxylate transporter 14; MCT 14; Solute carrier family 16 member 14
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAAPAPVTRQVSGAAALVPAPSGPDSGQPLAAAVAELPVLDARGQRVPFGALFRERRAVV
VFVRHFLCYICKEYVEDLAKIPRSFLQEANVTLIVIGQSSYHHIEPFCKLTGYSHEIYVD
PEREIYKRLGMKRGEEIASSGQSPHIKSNLLSGSLQSLWRAVTGPLFDFQGDPAQQGGTL
ILGPGNNIHFIHRDRNRLDHKPINSVLQLVGVQHVNFTNRPSVIHV
Target Bioclass
Transporter and channel
Family
Major facilitator superfamily, Monocarboxylate porter (TC 2.A.1.13) family
Subcellular location
Cell membrane
Function Proton-linked monocarboxylate transporter. May catalyze the transport of monocarboxylates across the plasma membrane.
Uniprot ID
Q7RTX9
Ensemble ID
ENST00000295190.9
HGNC ID
HGNC:26417

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
COLO829 SNV: p.E247K .
DU145 SNV: p.Y125H .
HCT116 Deletion: p.E248GfsTer96
SNV: p.A184V;p.H363R		 .
HEC1B SNV: p.Y421D .
HS936T Substitution: p.L212H .
IPC298 SNV: p.G139W .
Ishikawa (Heraklio) 02 ER SNV: p.H66N .
LNCaP clone FGC SNV: p.P492Q .
MKN45 SNV: p.L289P .
NCIH358 SNV: p.E63K .
RT112 SNV: p.R292K .
SKMEL2 SNV: p.D250N .
SW1116 SNV: p.A439T .
TOV21G Deletion: p.K469NfsTer14 .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
NAIA_4
 Probe Info  		N.A.  LDD2226  [1]

References

1 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264