Details of the Target

General Information of Target

Target ID LDTP17492
Target Name Putative EP400-like protein (EP400P1)
Gene Name EP400P1
Synonyms
EP400NL; Putative EP400-like protein; EP400 pseudogene 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MWVNPEEVLLANALWITERANPYFILQRRKGHAGDGGGGGGLAGLLVGTLDVVLDSSARV
APYRILYQTPDSLVYWTIACGGSRKEITEHWEWLEQNLLQTLSIFENENDITTFVRGKIQ
GIIAEYNKINDVKEDDDTEKFKEAIVKFHRLFGMPEEEKLVNYYSCSYWKGKVPRQGWMY
LSINHLCFYSFLMGREAKLVIRWVDITQLEKNATLLLPDVIKVSTRSSEHFFSVFLNINE
TFKLMEQLANIAMRQLLDNEGFEQDRSLPKLKRKSPKKVSALKRDLDARAKSERYRALFR
LPKDEKLDGHTDCTLWTPFNKMHILGQMFVSTNYICFTSKEENLCSLIIPLREVTIVEKA
DSSSVLPSPLSISTRNRMTFLFANLKDRDFLVQRISDFLQQTTSKIYSDKEFAGSYNSSD
DEVYSRPSSLVSSSPQRSTSSDADGERQFNLNGNSVPTATQTLMTMYRRRSPEEFNPKLA
KEFLKEQAWKIHFAEYGQGICMYRTEKTRELVLKGIPESMRGELWLLLSGAINEKATHPG
YYEDLVEKSMGKYNLATEEIERDLHRSLPEHPAFQNEMGIAALRRVLTAYAFRNPNIGYC
QAMNIVTSVLLLYAKEEEAFWLLVALCERMLPDYYNTRVVGALVDQGVFEELARDYVPQL
YDCMQDLGVISTISLSWFLTLFLSVMPFESAVVVVDCFFYEGIKVIFQLALAVLDANVDK
LLNCKDDGEAMTVLGRYLDSVTNKDSTLPPIPHLHSLLSDDVEPYPEVDIFRLIRTSYEK
FGTIRADLIEQMRFKQRLKVIQTLEDTTKRNVVRTIVTETSFTIDELEELYALFKAEHLT
SCYWGGSSNALDRHDPSLPYLEQYRIDFEQFKGMFALLFPWACGTHSDVLASRLFQLLDE
NGDSLINFREFVSGLSAACHGDLTEKLKLLYKMHVLPEPSSDQDEPDSAFEATQYFFEDI
TPECTHVVGLDSRSKQGADDGFVTVSLKPDKGKRANSQENRNYLRLWTPENKSKSKNAKD
LPKLNQGQFIELCKTMYNMFSEDPNEQELYHATAAVTSLLLEIGEVGKLFVAQPAKEGGS
GGSGPSCHQGIPGVLFPKKGPGQPYVVESVEPLPASLAPDSEEHSLGGQMEDIKLEDSSP
RDNGACSSMLISDDDTKDDSSMSSYSVLSAGSHEEDKLHCEDIGEDTVLVRSGQGTAALP
RSTSLDRDWAITFEQFLASLLTEPALVKYFDKPVCMMARITSAKNIRMMGKPLTSASDYE
ISAMSG
Target Bioclass
Other
Uniprot ID
Q6ZTU2
HGNC ID
HGNC:26602

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C151(1.01)  LDD1507  [1]
VSF
 Probe Info  		N.A.  LDD0007  [2]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C151(1.01)  LDD1507  [1]
 LDCM0276  AC17 HEK-293T C151(1.12)  LDD1515  [1]
 LDCM0285  AC25 HEK-293T C151(1.08)  LDD1524  [1]
 LDCM0294  AC33 HEK-293T C151(0.98)  LDD1533  [1]
 LDCM0303  AC41 HEK-293T C151(1.19)  LDD1542  [1]
 LDCM0311  AC49 HEK-293T C151(1.09)  LDD1550  [1]
 LDCM0320  AC57 HEK-293T C151(0.95)  LDD1559  [1]
 LDCM0356  AKOS034007680 HEK-293T C151(1.06)  LDD1570  [1]
 LDCM0371  CL102 HEK-293T C357(1.14)  LDD1575  [1]
 LDCM0375  CL106 HEK-293T C357(0.94)  LDD1579  [1]
 LDCM0380  CL110 HEK-293T C357(1.08)  LDD1584  [1]
 LDCM0384  CL114 HEK-293T C357(1.05)  LDD1588  [1]
 LDCM0388  CL118 HEK-293T C357(1.02)  LDD1592  [1]
 LDCM0393  CL122 HEK-293T C357(1.00)  LDD1597  [1]
 LDCM0397  CL126 HEK-293T C357(1.10)  LDD1601  [1]
 LDCM0401  CL14 HEK-293T C357(1.18)  LDD1605  [1]
 LDCM0404  CL17 HEK-293T C151(1.04)  LDD1608  [1]
 LDCM0407  CL2 HEK-293T C357(1.00)  LDD1611  [1]
 LDCM0414  CL26 HEK-293T C357(0.99)  LDD1618  [1]
 LDCM0417  CL29 HEK-293T C151(1.19)  LDD1621  [1]
 LDCM0431  CL41 HEK-293T C151(1.11)  LDD1635  [1]
 LDCM0440  CL5 HEK-293T C151(1.24)  LDD1644  [1]
 LDCM0441  CL50 HEK-293T C357(1.13)  LDD1645  [1]
 LDCM0444  CL53 HEK-293T C151(0.96)  LDD1647  [1]
 LDCM0454  CL62 HEK-293T C357(1.10)  LDD1657  [1]
 LDCM0457  CL65 HEK-293T C151(1.17)  LDD1660  [1]
 LDCM0467  CL74 HEK-293T C357(0.86)  LDD1670  [1]
 LDCM0470  CL77 HEK-293T C151(0.94)  LDD1673  [1]
 LDCM0480  CL86 HEK-293T C357(1.17)  LDD1683  [1]
 LDCM0483  CL89 HEK-293T C151(1.05)  LDD1686  [1]
 LDCM0493  CL98 HEK-293T C357(1.01)  LDD1696  [1]
 LDCM0427  Fragment51 HEK-293T C357(1.04)  LDD1631  [1]

References

1 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
2 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
3 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004