Details of the Target

General Information of Target

Target ID LDTP17469
Target Name Ferric-chelate reductase 1 (FRRS1)
Gene Name FRRS1
Gene ID 391059
Synonyms
SDFR2; SDR2; Ferric-chelate reductase 1; EC 1.-.-.-; Stromal cell-derived receptor 2; SDR-2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MALTQGPLTFRDVAIEFSQEEWKSLDPVQKALYWDVMLENYRNLVFLGILPKCMTKELPP
IGNSNTGEKCQTVTLERHECYDVENFYLREIQKNLQDLEFQWKDGEINYKEVPMTYKNNL
NGKRGQHSQEDVENKCIENQLTLSFQSRLTELQKFQTEGKIYECNQSEKTVNNSSLVSPL
QRILPSVQTNISKKYENEFLQLSLPTQLEKTHIREKPYMCKGCGKAFRVSSSLINHQMVH
TTEKPYKCNECGKAFHRGSLLTIHQIVHTRGKPYQCGVCGKIFRQNSDLVNHRRSHTGEK
PYKCNECGKSFSQSYNLAIHQRIHTGEKPYKCNECGKTFKQGSCLTTHQIIHTGEKPYQC
DICGKVFRQNSNLVNHQRIHTGEKPYKCNICGKSFSQSSNLATHQTVHSGNKPYKCDECG
KTFKRSSSLTTHQIIHTGEKPYTCDVCDKVFSQRSQLARHQRSHTGEKPYKCNECGKVFS
QTSHLVGHRRIHTGEKPYKCDKCGKAFKQGSLLTRHKIIHTREKRYQCGECGKVFSENSC
LVRHLRIHTGEQPYKCNVCGKVFNYSGNLSIHKRIHTGEKPFQCNECGTVFRNYSCLARH
LRIHTGQKPYKCNVCGKVFNDSGNLSNHKRIHTGEKPFQCNECGKVFSYYSCLARHRKIH
TGEKPYKCNDCGKAYTQRSSLTKHLIIHTGEKPYNCNEFGGAFIQSSKLARYHRNPTGEK
PHKCSHCGRTFSHITGLTYHQRRHTGEMPYKCIECGQVFNSTSNLARHRRIHTGEKPYKC
NECGKVFRHQSTLARHRSIHTGEKPYVCNECGKAFRVRSILVNHQKMHTGDKPYKCNECG
KAFIERSKLVYHQRNHTGEKPYKCIECGKAFGRFSCLNKHQMIHSGEKPYKCNECGKSFI
SRSGLTKHQTKHTAESLKTKFNVEKPLDVLLTSGFK
Target Bioclass
Enzyme
Family
FRRS1 family
Subcellular location
Membrane
Function Ferric-chelate reductases reduce Fe(3+) to Fe(2+) before its transport from the endosome to the cytoplasm.
Uniprot ID
Q6ZNA5
Ensemble ID
ENST00000287474.9
HGNC ID
HGNC:27622

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A3KAW SNV: p.H341Q .
HCT15 SNV: p.I434T .
KASUMI1 SNV: p.P432R .
KMCH1 SNV: p.L346F .
LU65 SNV: p.M416V .
NCIH1793 SNV: p.G519Ter .
NUGC3 Insertion: p.T124NfsTer4 .
RL952 Insertion: p.T124NfsTer4 .
WM2664 Insertion: p.Q343PfsTer8 .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C211(3.01)  LDD3373  [1]
YN-1
 Probe Info  		S364(0.00); S366(0.00)  LDD0447  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 EoL-1 C211(1.84)  LDD2324  [1]
 LDCM0023  KB03 EoL-1 C211(4.97)  LDD2741  [1]
 LDCM0024  KB05 OCUG-1 C211(3.01)  LDD3373  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.