Details of the Target

General Information of Target

Target ID	LDTP17456
Target Name	Echinoderm microtubule-associated protein-like 6 (EML6)
Gene Name	EML6
Gene ID	400954
Synonyms	EML5L; Echinoderm microtubule-associated protein-like 6; EMAP-6; Echinoderm microtubule-associated protein-like 5-like
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MNTFQASVSFQDVTVEFSQEEWQHMGPVERTLYRDVMLENYSHLVSVGYCFTKPELIFTL EQGEDPWLLEKEKGFLSRNSPEDSQPDEISEKSPENQGKHLLQVLFTNKLLTTEQEISGK PHNRDINIFRARMMPCKCDIAGSACQGLSLMAPHCQYSKEKAHERNVCDKWLISIKDGRT NTQEKSFAYSKIVKTLHHKEEVIQHQTIQTLGQDFEYNESRKAFLEKAALVTSNSTHPKG KSYNFNKFGENKYDKSTFIIPQNMNPEKSHYEFNDTGNCFCRITHKTLTGGKSFSQKSHI REHHRVHIGVKPFEYGKSFNRNSTLPVHQRTHATDKYSDYHPCTETFSYQSTFSVHQKVH IRAKPYEYNECGKSCSMNSHLIWPQKSHTGEKPYECPECGKAFSEKSRLRKHQRTHTGEK PYKCDGCDKAFSAKSGLRIHQRTHTGEKPFECHECGKSFNYKSILIVHQRTHTGEKPFEC NECGKSFSHMSGLRNHRRTHTGERPYKCDECGKAFKLKSGLRKHHRTHTGEKPYKCNQCG KAFGQKSQLRGHHRIHTGEKPYKCNHCGEAFSQKSNLRVHHRTHTGEKPYQCEECGKTFR QKSNLRGHQRTHTGEKPYECNECGKAFSEKSVLRKHQRTHTGEKPYNCNQCGEAFSQKSN LRVHQRTHTGEKPYKCDKCGRTFSQKSSLREHQKAHPGD
Target Bioclass	Other
Family	WD repeat EMAP family
Subcellular location	Cytoplasm, cytoskeleton
Function	May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic.
Uniprot ID	Q6ZMW3
Ensemble ID	ENST00000356458.8
HGNC ID	HGNC:35412

Target Site Mutations in Different Cell Lines

Cell line	Mutation details	Probe for labeling this protein in this cell
22RV1	SNV: p.A1198V	.
AN3CA	Deletion: p.F1152LfsTer10	.
COLO829	SNV: p.A1448T	.
CORL23	SNV: p.G426R	.
HCT116	Deletion: p.F1152LfsTer10 Insertion: p.K1358EfsTer4	.
HCT15	Deletion: p.F1152LfsTer10	.
HEC1	SNV: p.M243V; p.R1650C	.
HEC1B	Deletion: p.K1357RfsTer9 SNV: p.R1650C	.
HT115	SNV: p.L767S; p.R1807H	.
IGROV1	Deletion: p.K1357RfsTer9	.
KYSE150	SNV: p.S1816T	.
MOLT4	Deletion: p.K838NfsTer29; p.N1675MfsTer7	.
NCIH1793	SNV: p.G582R	.
NCIH2286	SNV: p.W262L; p.V821A	.
NCIH446	Deletion: p.W177GfsTer8	.
OVK18	Deletion: p.F1152LfsTer10	.
RBE	SNV: p.S1403F	.
SKMEL30	Deletion: p.K543IfsTer3 SNV: p.K543N	.
SNU1	Deletion: p.K1357RfsTer9	.
TC71	SNV: p.W1002C	.

Probe(s) Labeling This Target

ABPP Probe

Click To Hide/Show 2 Probe Related to This Target

Probe name		Structure	Binding Site(Ratio)	Interaction ID	Ref
IPM Probe Info			N.A.	LDD0241	[1]
YN-1 Probe Info			E1667(0.00); E1670(0.00)	LDD0447	[2]

References

1	Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
2	Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.