Details of the Target

General Information of Target

Target ID LDTP17454
Target Name Protein PPP4R3C (PPP4R3C)
Gene Name PPP4R3C
Synonyms
PPP4R3CP; SMEK3P; Protein PPP4R3C; SMEK homolog 3; Serine/threonine-protein phosphatase 4 regulatory subunit 3C
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MASGAQLPPQPSSSEVSAVQSPGGRPGAGLEETALGVPLPPSPGEAPLPRSNRSRCPGTR
QPGAASLHAASAAVPVRPRRGTAPAGKTADAVPAAAPEQAPRPAPQSRKPRNLEGDLDER
RLLCHLQLAQDREARLWRGGKPQDEICDAFEEVVLWLLRLQNTFYFSQSTFNLALTIFGR
LLISVKVKEKYLHCATITSLRLAAKVNEEEEFIPQVKDFTKHYGSDYSPNELLRMELAIL
DRLHWDLYIGTPLDFLTIFHALVVLSWPHVLELLPQRNPSLHVASLTRQLQHCMAGHQLL
QFKGSTLALVIITLELERLMPGWCAPISDLLKKAQVGDMQYSCCKELVMQQLRSLQSSSC
TDNFVSPAN
Target Bioclass
Enzyme
Family
SMEK family
Uniprot ID
Q6ZMV5
Ensemble ID
ENST00000412172.4
HGNC ID
HGNC:33146

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
EFO27 SNV: p.L13P .
HCT116 SNV: p.D146G; p.T427I .
HCT15 SNV: p.H192Y .
HT115 SNV: p.K311T .
HT1376 SNV: p.A170T .
IGROV1 Deletion: p.F337SfsTer23
SNV: p.A689V		 .
JHH7 SNV: p.K103E .
MCC13 SNV: p.P173S; p.G641R; p.M749I .
MKN45 SNV: p.E756Ter .
RKO SNV: p.D375Y .
T98G SNV: p.C98R .
WM2664 Insertion: p.E804GfsTer8 .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C331(5.27); C781(2.89)  LDD3331  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 MKN-1 C331(2.13); C781(2.45)  LDD2497  [1]
 LDCM0023  KB03 MKN-1 C331(3.69); C781(2.56)  LDD2914  [1]
 LDCM0024  KB05 MKN-1 C331(5.27); C781(2.89)  LDD3331  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840