Details of the Target

General Information of Target

Target ID LDTP17452
Target Name PDZ domain-containing RING finger protein 4 (PDZRN4)
Gene Name PDZRN4
Gene ID 29951
Synonyms
LNX4; SEMCAP3L; PDZ domain-containing RING finger protein 4; Ligand of Numb protein X 4; SEMACAP3-like protein
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MSNVSGILETAGVPLVSANWPQPSPPPAVPAGPQMDHMGNSSQGAPWLFLTSALARGVSG
IFVWTALVLTCHQIYLHLRSYTVPQEQRYIIRLLLIVPIYAFDSWLSLLLLGDHQYYVYF
DSVRDCYEAFVIYSFLSLCFQYLGGEGAIMAEIRGKPIKSSCLYGTCCLRGMTYSIGFLR
FCKQATLQFCLVKPVMAVTTIILQAFGKYHDGDFNVRSGYLYVTLIYNASVSLALYALFL
FYFTTRELLRPFQPVLKFLTIKAVIFLSFWQGLLLAILERCGVIPEVETSGGNKLGAGTL
AAGYQNFIICVEMLFASVALRYAFPCQVYAEKKENSPAPPAPMQSISSGIRETVSPQDIV
QDAIHNFSPAYQHYTQQATHEAPRPGTHPSGGSGGSRKSRSLEKRMLIPSEDL
Target Bioclass
Other
Uniprot ID
Q6ZMN7
Ensemble ID
ENST00000298919.7
HGNC ID
HGNC:30552

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CAMA1 SNV: p.R158Q .
DU145 SNV: p.R84S; p.R638Ter .
EFO27 SNV: p.P975S .
FTC133 SNV: p.N301D .
HCC15 Deletion: p.K285RfsTer27 .
HCT116 SNV: p.L750F .
HCT15 SNV: p.Q869R .
HT115 SNV: p.R242Ter .
HUH7 SNV: p.R586G .
IGROV1 SNV: p.G272R .
IM95 SNV: p.P32L .
KMCH1 SNV: p.L416P .
KYSE510 SNV: p.A542E .
LN18 SNV: p.M935K .
MKN1 SNV: p.L287I .
MOLT4 SNV: p.S895G .
NCIH1793 SNV: p.D13Y; p.H35Q .
NCIH2170 SNV: p.R638L .
OPM2 SNV: p.K769N .
OVK18 SNV: p.Q851R .
SH4 SNV: p.A11S .
SNU1 SNV: p.M716V .
SUPT1 SNV: p.M932T .
SW756 SNV: p.E789Q .
SW948 SNV: p.P355L .
TE10 SNV: p.G34W .
TKKK SNV: p.R113C .
WM2664 Insertion: p.V185GfsTer37 .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C436(1.26)  LDD3344  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 A101D C436(1.60)  LDD2250  [1]
 LDCM0023  KB03 A101D C436(1.52)  LDD2667  [1]
 LDCM0024  KB05 NCI-H146 C436(1.26)  LDD3344  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840