Details of the Target

General Information of Target

Target ID LDTP17438
Target Name Transmembrane protein 92 (TMEM92)
Gene Name TMEM92
Gene ID 162461
Synonyms
Transmembrane protein 92
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPPWGAALALILAVLALLGLLGPRLRGPWGRAVGERTLPGAQDRDDGEEADGGGPADQFS
DGREPLPGGCSLVCKPSALAQCLLRALRRSEALEAGPRSWFSGPHLQTLCHFVLPVAPGP
ELAREYLQLADDGLVALDWVVGPCVRGRRITSAGGLPAVLLVIPNAWGRLTRNVLGLCLL
ALERGYYPVIFHRRGHHGCPLVSPRLQPFGDPSDLKEAVTYIRFRHPAAPLFAVSEGSGS
ALLLSYLGECGSSSYVTGAACISPVLRCREWFEAGLPWPYERGFLLHQKIALSRYATALE
DTVDTSRLFRSRSLREFEEALFCHTKSFPISWDTYWDRNDPLRDVDEAAVPVLCICSADD
PVCGPPDHTLTTELFHSNPYFFLLLSRHGGHCGFLRQEPLPAWSHEVILESFRALTEFFR
TEERIKGLSRHRASFLGGRRRGGALQRREVSSSSNLEEIFNWKRSYTR
Target Bioclass
Other
Subcellular location
Membrane
Uniprot ID
Q6UXU6
Ensemble ID
ENST00000300433.7
HGNC ID
HGNC:26579

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
BTD
 Probe Info  		C28(1.01)  LDD2092  [1]
IPM
 Probe Info  		C28(1.74)  LDD1702  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C28(1.74)  LDD1702  [1]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C28(1.01)  LDD2092  [1]

References

1 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761