Details of the Target

General Information of Target

Target ID LDTP17429
Target Name XK-related protein 5 (XKR5)
Gene Name XKR5
Gene ID 389610
Synonyms
XRG5; XK-related protein 5
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGLPGLFCLAVLAASSFSKAREEEITPVVSIAYKVLEVFPKGRWVLITCCAPQPPPPITY
SLCGTKNIKVAKKVVKTHEPASFNLNVTLKSSPDLLTYFCWASSTSGAHVDSARLQMHWE
LWSKPVSELRANFTLQDRGAGPRVEMICQASSGSPPITNSLIGKDGQVHLQQRPCHRQPA
NFSFLPSQTSDWFWCQAANNANVQHSALTVVPPGGDQKMEDWQGPLESPILALPLYRSTR
RLSEEEFGGFRIGNGEVRGRKAAAM
Target Bioclass
Transporter and channel
Family
XK family
Subcellular location
Cell membrane
Uniprot ID
Q6UX68
Ensemble ID
ENST00000618742.3
HGNC ID
HGNC:20782

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AU565 SNV: p.S368R .
COLO678 SNV: p.F240V .
HCT15 SNV: p.H72Y; p.A177V; p.W407R .
HEC1 Insertion: p.A289GfsTer52 .
KMRC20 SNV: p.L114R .
MELJUSO SNV: p.R261K .
NCIH1155 SNV: p.Q227Ter; p.C364Y .
NCIH1793 SNV: p.E514Ter .
P31FUJ SNV: p.G609C .
SW403 SNV: p.S53R .
TOV21G SNV: p.T88P .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Acrolein
 Probe Info  		N.A.  LDD0233  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0109  NEM HeLa N.A.  LDD0233  [1]

References

1 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.