Details of the Target

General Information of Target

Target ID LDTP17426
Target Name HHIP-like protein 2 (HHIPL2)
Gene Name HHIPL2
Gene ID 79802
Synonyms
HHIP3; KIAA1822L; HHIP-like protein 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSGACTSYVSAEQEVVRGFSCPRPGGEAAAVFCCGFRDHKYCCDDPHSFFPYEHSYMWWL
SIGALIGLSVAAVVLLAFIVTACVLCYLFISSKPHTKLDLGLSLQTAGPEEVSPDCQGVN
TGMAAEVPKVSPLQQSYSCLNPQLESNEGQAVNSKRLLHHCFMATVTTSDIPGSPEEASV
PNPDLCGPVP
Target Bioclass
Other
Family
HHIP family
Subcellular location
Secreted
Uniprot ID
Q6UWX4
Ensemble ID
ENST00000343410.7
HGNC ID
HGNC:25842

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C169(0.92); C472(0.87)  LDD0078  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0020  ARS-1620 HCC44 C169(0.92); C472(0.87)  LDD0078  [1]
 LDCM0022  KB02 COR-L23 C472(1.76)  LDD2310  [2]
 LDCM0023  KB03 HCC44 C472(4.42)  LDD2761  [2]
 LDCM0024  KB05 NCI-H1299 C472(2.73)  LDD3343  [2]

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840