Details of the Target

General Information of Target

Target ID LDTP17424
Target Name Beta-galactosidase-1-like protein (GLB1L)
Gene Name GLB1L
Gene ID 79411
Synonyms
Beta-galactosidase-1-like protein; EC 3.2.1.-
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGAAISQGALIAIVCNGLVGFLLLLLWVILCWACHSRSADVDSLSESSPNSSPGPCPEKA
PPPQKPSHEGSYLLQP
Target Bioclass
Enzyme
Family
Glycosyl hydrolase 35 family
Subcellular location
Secreted
Function Probable glycosyl hydrolase.
Uniprot ID
Q6UWU2
Ensemble ID
ENST00000295759.12
HGNC ID
HGNC:28129

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CAL62 SNV: p.I424V .
HCT15 SNV: p.G552V; p.P595H .
HT SNV: p.P523L .
HT29 SNV: p.L345P .
NCIH1793 SNV: p.A109E .
RL952 SNV: p.T19M .
TE4 SNV: p.P395H .
U937 SNV: p.W170R .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C62(3.24)  LDD3430  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 A101D C62(1.39)  LDD2250  [1]
 LDCM0023  KB03 A101D C62(1.55)  LDD2667  [1]
 LDCM0024  KB05 SK-MEL-5 C62(3.24)  LDD3430  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840