Details of the Target

General Information of Target

Target ID LDTP17411
Target Name Surfactant-associated protein 2 (SFTA2)
Gene Name SFTA2
Gene ID 389376
Synonyms
SFTPG; Surfactant-associated protein 2; Surfactant-associated protein G; SP-G
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MLDFAIFAVTFLLALVGAVLYLYPASRQAAGIPGITPTEEKDGNLPDIVNSGSLHEFLVN
LHERYGPVVSFWFGRRLVVSLGTVDVLKQHINPNKTSDPFETMLKSLLRYQSGGGSVSEN
HMRKKLYENGVTDSLKSNFALLLKLSEELLDKWLSYPETQHVPLSQHMLGFAMKSVTQMV
MGSTFEDDQEVIRFQKNHGTVWSEIGKGFLDGSLDKNMTRKKQYEDALMQLESVLRNIIK
ERKGRNFSQHIFIDSLVQGNLNDQQILEDSMIFSLASCIITAKLCTWAICFLTTSEEVQK
KLYEEINQVFGNGPVTPEKIEQLRYCQHVLCETVRTAKLTPVSAQLQDIEGKIDRFIIPR
ETLVLYALGVVLQDPNTWPSPHKFDPDRFDDELVMKTFSSLGFSGTQECPELRFAYMVTT
VLLSVLVKRLHLLSVEGQVIETKYELVTSSREEAWITVSKRY
Target Bioclass
Other
Subcellular location
Secreted
Function Putative surfactant protein.
Uniprot ID
Q6UW10
Ensemble ID
ENST00000359086.4
HGNC ID
HGNC:18386

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C76(4.00)  LDD3472  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 ICC18 C76(1.58)  LDD2385  [1]
 LDCM0023  KB03 ICC3 C76(1.73)  LDD2808  [1]
 LDCM0024  KB05 TFK-1 C76(4.00)  LDD3472  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840