Details of the Target

General Information of Target

Target ID LDTP17405
Target Name Coiled-coil domain-containing protein 171 (CCDC171)
Gene Name CCDC171
Gene ID 203238
Synonyms
C9orf93; Coiled-coil domain-containing protein 171
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAFQDLLDQVGGLGRFQILQMVFLIMFNVIVYHQTQLENFAAFILDHRCWVHILDNDTIP
DNDPGTLSQDALLRISIPFDSNLRPEKCRRFVHPQWKLIHLNGTFPNTSEPDTEPCVDGW
VYDQSSFPSTIVTKWDLVCESQPLNSVAKFLFMAGMMVGGNLYGHLSDRFGRKFVLRWSY
LQLAIVGTCAAFAPTILVYCSLRFLAGAATFSIIVNTVLLIVEWITHQFCAMALTLTLCA
ASIGHITLGSLAFVIRDQCILQLVMSAPCFVFFLFSRWLAESARWLIINNKPEEGLKELR
KAAHRNGMKNAEDILTMEVLKSTMKQELEAAQKKHSLCELLRIPNICKRICFLSFVRFAS
TIPFWGLTLHLQHLGNNVFLLQTLFGAVTLLANCVAPWALNHMSRRLSQMLLMFLLATCL
LAIIFVPQEMQTLRVVLATLGVGAASLGITCSTAQENELIPSIIRGRATGITGNFANIGG
ALASLMMILSIYSRPLPWIIYGVFAILSGLVVLLLPETRNQPLLDSIQDVENEGVNSLAA
PQRSSVL
Target Bioclass
Other
Uniprot ID
Q6TFL3
Ensemble ID
ENST00000380701.8
HGNC ID
HGNC:29828

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 SNV: p.A970T .
ABC1 SNV: p.I223T .
CAL78 SNV: p.H1032N .
COLO792 SNV: p.S430N .
CORL23 Substitution: p.T127S .
DU145 SNV: p.S321N .
HCC70 SNV: p.E244Q .
HEC1B SNV: p.A810T .
HT SNV: p.V22A .
KPL1 SNV: p.E551V .
LS180 Deletion: p.N692TfsTer5 .
MCF7 SNV: p.E551V .
OCUG1 SNV: p.E363K .
OVKATE SNV: p.A689T .
P31FUJ Insertion: p.N692KfsTer6 .
PC9 SNV: p.N157S .
SNGM SNV: p.L614I .
SNU423 SNV: p.S1310A .
WM2664 Insertion: p.V997GfsTer10 .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Acrolein
 Probe Info  		N.A.  LDD0233  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0109  NEM HeLa N.A.  LDD0233  [1]

References

1 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.