Details of the Target

General Information of Target

Target ID LDTP17397
Target Name Coiled-coil domain-containing protein 137 (CCDC137)
Gene Name CCDC137
Gene ID 339230
Synonyms
cPERP-B; Coiled-coil domain-containing protein 137
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MVCSPVTLRIAPPDRRFSRSAIPEQIISSTLSSPSSNAPDPCAKETVLSALKEKKKKRTV
EEEDQIFLDGQENKRSCLVDGLTDASSAFKVPRPGPDTLQFTVDVFHFANDSRNMIYITC
HLKVTLAEQDPDELNKACSFSKPSNSWFPVEGLADICQCCNKGDCGTPSHSRRQPRVVSQ
WSTSASL
Target Bioclass
Other
Subcellular location
Chromosome
Uniprot ID
Q6PK04
Ensemble ID
ENST00000329214.13
HGNC ID
HGNC:33451

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
ONAyne
 Probe Info  		K283(10.00)  LDD0274  [2]
BTD
 Probe Info  		C53(0.56)  LDD1700  [3]
Acrolein
 Probe Info  		N.A.  LDD0223  [4]
ATP probe
 Probe Info  		N.A.  LDD0199  [5]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [6]
IPM
 Probe Info  		N.A.  LDD0147  [7]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [8]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0156  Aniline NCI-H1299 13.17  LDD0403  [1]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C53(1.05)  LDD1702  [3]
 LDCM0023  KB03 MDA-MB-231 C53(1.43)  LDD1701  [3]
 LDCM0109  NEM HeLa N.A.  LDD0223  [4]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C53(1.08)  LDD2092  [3]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C53(1.52)  LDD2094  [3]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C53(0.50)  LDD2096  [3]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C53(0.52)  LDD2098  [3]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C53(0.51)  LDD2099  [3]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C53(0.48)  LDD2109  [3]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C53(0.44)  LDD2111  [3]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C53(0.73)  LDD2116  [3]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C53(0.71)  LDD2118  [3]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C53(3.38)  LDD2119  [3]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C53(1.00)  LDD2122  [3]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C53(0.69)  LDD2124  [3]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C53(0.44)  LDD2125  [3]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C53(1.41)  LDD2126  [3]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C53(1.47)  LDD2128  [3]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C53(0.77)  LDD2136  [3]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C53(0.56)  LDD1700  [3]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C53(0.26)  LDD2140  [3]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C53(2.08)  LDD2143  [3]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C53(0.96)  LDD2149  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Telomeric repeat-binding factor 2 (TERF2) . Q15554

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
5 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
6 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
7 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
8 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004