Details of the Target

General Information of Target

Target ID LDTP17393
Target Name Hydroxyacylglutathione hydrolase-like protein (HAGHL)
Gene Name HAGHL
Gene ID 84264
Synonyms
Hydroxyacylglutathione hydrolase-like protein; EC 3.1.2.-
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MASFGWKRKIGEKVSKVTSQQFEAEAADEKDVVDNDEGNWLHAIKRRKEILLEGCAEKSK
QLKDEGASLAENKRYREAIQKWDEALQLTPNDATLYEMKSQVLMSLHEMFPAVHAAEMAV
QQNPHSWESWQTLGRAQLGLGEIILAIRSFQVALHIYPMNPEIWKEDLSWARTLQEQQKV
AQRIKKSEAPAEVTHFSPKSIPDYDFESDEIVAVCAAIAEKEKTVSANKTMVIVSASGAI
ETVTEKEDGATPPDGSVFIKAR
Target Bioclass
Enzyme
Family
Metallo-beta-lactamase superfamily, Glyoxalase II family
Function Hydrolase acting on ester bonds.
Uniprot ID
Q6PII5
Ensemble ID
ENST00000341413.8
HGNC ID
HGNC:14177

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C188(1.07)  LDD3312  [1]
IPM
 Probe Info  		N.A.  LDD0147  [2]
NAIA_5
 Probe Info  		N.A.  LDD2223  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HEK-293T C188(0.94)  LDD1508  [4]
 LDCM0277  AC18 HEK-293T C188(0.86)  LDD1516  [4]
 LDCM0279  AC2 HEK-293T C188(0.96)  LDD1518  [4]
 LDCM0281  AC21 HEK-293T C188(1.09)  LDD1520  [4]
 LDCM0286  AC26 HEK-293T C188(0.95)  LDD1525  [4]
 LDCM0289  AC29 HEK-293T C188(1.11)  LDD1528  [4]
 LDCM0295  AC34 HEK-293T C188(1.03)  LDD1534  [4]
 LDCM0298  AC37 HEK-293T C188(0.94)  LDD1537  [4]
 LDCM0304  AC42 HEK-293T C188(0.88)  LDD1543  [4]
 LDCM0307  AC45 HEK-293T C188(1.01)  LDD1546  [4]
 LDCM0312  AC5 HEK-293T C188(0.93)  LDD1551  [4]
 LDCM0313  AC50 HEK-293T C188(0.92)  LDD1552  [4]
 LDCM0316  AC53 HEK-293T C188(1.03)  LDD1555  [4]
 LDCM0321  AC58 HEK-293T C188(0.88)  LDD1560  [4]
 LDCM0325  AC61 HEK-293T C188(1.04)  LDD1564  [4]
 LDCM0248  AKOS034007472 HEK-293T C188(1.13)  LDD1511  [4]
 LDCM0405  CL18 HEK-293T C188(0.94)  LDD1609  [4]
 LDCM0409  CL21 HEK-293T C188(0.98)  LDD1613  [4]
 LDCM0419  CL30 HEK-293T C188(0.96)  LDD1623  [4]
 LDCM0422  CL33 HEK-293T C188(1.02)  LDD1626  [4]
 LDCM0432  CL42 HEK-293T C188(0.92)  LDD1636  [4]
 LDCM0435  CL45 HEK-293T C188(0.91)  LDD1639  [4]
 LDCM0445  CL54 HEK-293T C188(0.82)  LDD1648  [4]
 LDCM0448  CL57 HEK-293T C188(0.93)  LDD1651  [4]
 LDCM0451  CL6 HEK-293T C188(0.93)  LDD1654  [4]
 LDCM0458  CL66 HEK-293T C188(0.99)  LDD1661  [4]
 LDCM0461  CL69 HEK-293T C188(1.15)  LDD1664  [4]
 LDCM0471  CL78 HEK-293T C188(0.89)  LDD1674  [4]
 LDCM0475  CL81 HEK-293T C188(1.20)  LDD1678  [4]
 LDCM0484  CL9 HEK-293T C188(1.01)  LDD1687  [4]
 LDCM0485  CL90 HEK-293T C188(0.85)  LDD1688  [4]
 LDCM0488  CL93 HEK-293T C188(1.07)  LDD1691  [4]
 LDCM0022  KB02 HEK-293T C188(0.77)  LDD1492  [4]
 LDCM0023  KB03 HEK-293T C188(0.88)  LDD1497  [4]
 LDCM0024  KB05 HMCB C188(1.07)  LDD3312  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
3 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
4 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402