Details of the Target

General Information of Target

Target ID LDTP17381
Target Name Protein FAM171B (FAM171B)
Gene Name FAM171B
Gene ID 165215
Synonyms
KIAA1946; Protein FAM171B
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAQPGDPRRLCRLVQEGRLRALKEELQAAGGCPGPAGDTLLHCAARHGHRDVLAYLAEAW
GMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAAVDCLKKADWTPLMMACTRKNLGVI
QELVEHGANPLLKNKDGWNSFHIASREGDPLILQYLLTVCPGAWKTESKIRRTPLHTAAM
HGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQCGHIDVARLLLDEHGACLSAEDSLGA
QALHRAAVTGQDEAIRFLVSELGVDVDVRATSTHLTALHYAAKEGHTSTIQTLLSLGADI
NSKDEKNRSALHLACAGQHLACAKFLLQSGLKDSEDITGTLAQQLPRRADVLQGSGHSAM
T
Target Bioclass
Other
Family
FAM171 family
Subcellular location
Membrane
Uniprot ID
Q6P995
Ensemble ID
ENST00000304698.10
HGNC ID
HGNC:29412

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCT15 SNV: p.K665N .
HS936T SNV: p.L658H .
HT115 SNV: p.K346N; p.P614T; p.R697I .
LS180 Insertion: p.S647FfsTer32 .
MCC13 SNV: p.P437S .
MEWO Substitution: p.V26G .
OPM2 SNV: p.I771S .
RT112 SNV: p.K431Q .
SHP77 SNV: p.N792S .
TCCSUP SNV: p.L720P .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IA-alkyne
 Probe Info  		N.A.  LDD0161  [1]

References

1 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060