Details of the Target | Chem(Pro)²

General Information of Target

Target ID	LDTP17375
Target Name	Zinc finger protein 585A (ZNF585A)
Gene Name	ZNF585A
Gene ID	199704
Synonyms	Zinc finger protein 585A
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MDKYDVIKAIGQGAFGKAYLAKGKSDSKHCVIKEINFEKMPIQEKEASKKEVILLEKMKH PNIVAFFNSFQENGRLFIVMEYCDGGDLMKRINRQRGVLFSEDQILGWFVQISLGLKHIH DRKILHRDIKAQNIFLSKNGMVAKLGDFGIARVLNNSMELARTCIGTPYYLSPEICQNKP YNNKTDIWSLGCVLYELCTLKHPFEGNNLQQLVLKICQAHFAPISPGFSRELHSLISQLF QVSPRDRPSINSILKRPFLENLIPKYLTPEVIQEEFSHMLICRAGAPASRHAGKVVQKCK IQKVRFQGKCPPRSRISVPIKRNAILHRNEWRPPAGAQKARSIKMIERPKIAAVCGHYDY YYAQLDMLRRRAHKPSYHPIPQENTGVEDYGQETRHGPSPSQWPAEYLQRKFEAQQYKLK VEKQLGLRPSSAEPNYNQRQELRSNGEEPRFQELPFRKNEMKEQEYWKQLEEIRQQYHND MKEIRKKMGREPEENSKISHKTYLVKKSNLPVHQDASEGEAPVQMEFRSCCPGWSAMARS WLTATSASQDIEKDLKQMRLQNTKESKNPEQKYKAKKGVKFEINLDKCISDENILQEEEA MDIPNETLTFEDGMKFKEYECVKEHGDYTDKAFEKLHCPEAGFSTQTVAAVGNRRQWDGG APQTLLQMMAVADITSTCPTGPDSESVLSVSRQEGKTKDPYSPVLILM
Target Bioclass	Transcription factor
Family	Krueppel C2H2-type zinc-finger protein family
Subcellular location	Nucleus
Function	May be involved in transcriptional regulation.
Uniprot ID	Q6P3V2
Ensemble ID	ENST00000292841.10
HGNC ID	HGNC:26305

Target Site Mutations in Different Cell Lines

Cell line	Mutation details			Probe for labeling this protein in this cell
HCC1954	SNV: p.I495M			.
HUPT4	SNV: p.G222S			.
Ishikawa (Heraklio) 02 ER	SNV: p.K212I			.
JVM3	SNV: p.Q452Ter			.
KATOIII	SNV: p.L369F			.
MEWO	Substitution: p.I599Y			.
NCIH446	SNV: p.I539M			.
SNU1	Deletion: p.K702NfsTer32			.
T24	SNV: p.R458G			.
TE10	SNV: p.N337S			.
TE11	SNV: p.T526A			.
WM115	SNV: p.S200F			.
WM2664	SNV: p.S200F			.

Probe(s) Labeling This Target

ABPP Probe

Click To Hide/Show 2 Probe Related to This Target

Probe name		Structure	Binding Site(Ratio)	Interaction ID	Ref
IPM Probe Info			C440(1.02)	LDD1702	[1]
N1 Probe Info			S644(0.00); S650(0.00)	LDD0245	[2]

Competitor(s) Related to This Target

Competitor ID	Name	Cell line	Binding Site(Ratio)	Interaction ID	Ref
LDCM0213	Electrophilic fragment 2	MDA-MB-231	C440(1.02)	LDD1702	[1]

References

1	Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29. Mass spectrometry data entry: PXD039908 , PXD029761
2	Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.