Details of the Target

General Information of Target

Target ID LDTP17369
Target Name Arylacetamide deacetylase-like 2 (AADACL2)
Gene Name AADACL2
Gene ID 344752
Synonyms
Arylacetamide deacetylase-like 2; EC 3.1.1.-
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MESRKDITNQEEIWKMKPRRNLEDNDYLQTAHADEFDCPSELQHAQELFPQWHLPIKIAA
VMASLTFLYTLLREVIHPLATSHQQYFYKIPILVINKVLPMVSITLLALVYLPGVIAAIV
QVHNGTKYKKFPHWLDKWMLTRKQFGLLSLFFAVLHAIYTLSYAMRRSYRYKLLNWAYQQ
VQQNKEDAWIEHDVWRMEIYVSLGIVGLAILALLAVTSIPSVSDSLTWREFHYIQVHGRI
NFLTL
Target Bioclass
Enzyme
Family
'GDXG' lipolytic enzyme family
Subcellular location
Secreted
Uniprot ID
Q6P093
Ensemble ID
ENST00000356517.4
HGNC ID
HGNC:24427

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A431 SNV: p.R57T .
COLO792 SNV: p.C7G; p.P180L .
HCT15 SNV: p.P271H .
KMCH1 SNV: p.D83H .
LN18 SNV: p.L14P .
NCIH2286 SNV: p.A163E .
RL952 SNV: p.P288L .
SH4 SNV: p.G177E .
UACC257 SNV: p.Q360Ter .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IA-alkyne
 Probe Info  		C598(0.00); C1080(0.00)  LDD0161  [1]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Gibberellic Acid . DB07814
Gibberellin A4 . DB07815

References

1 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060