Details of the Target

General Information of Target

Target ID LDTP17360
Target Name Jhy protein homolog (JHY)
Gene Name JHY
Gene ID 79864
Synonyms
C11orf63; Jhy protein homolog
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPGCRISACGPGAQEGTAEQRSPPPPWDPMPSSQPPPPTPTLTPTPTPGQSPPLPDAAGA
SAGAAEDQELQRWRQGASGIAGLAGPGGGSGAAAGAGGRALELAEARRRLLEVEGRRRLV
SELESRVLQLHRVFLAAELRLAHRAESLSRLSGGVAQAELYLAAHGSRLKKGPRRGRRGR
PPALLASALGLGGCVPWGAGRLRRGHGPEPDSPFRRSPPRGPASPQR
Target Bioclass
Other
Function Required for the normal development of cilia in brain ependymal cells lining the ventricular surfaces.
Uniprot ID
Q6NUN7
Ensemble ID
ENST00000227349.7
HGNC ID
HGNC:26288

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
DETROIT562 SNV: p.N342I .
HCC44 SNV: p.W332C .
HCC70 SNV: p.P726Q .
HEC1 SNV: p.S272Y; p.D561Y .
HEC1B SNV: p.D561Y .
HGC27 SNV: p.S696Ter .
HT115 SNV: p.L505F .
IM95 Deletion: p.L196Ter .
Ishikawa (Heraklio) 02 ER SNV: p.V778A .
LS123 SNV: p.P411H .
MCC13 SNV: p.D125N .
NCIH1793 SNV: p.E87Ter .
RKO Deletion: p.R281EfsTer15 .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Acrolein
 Probe Info  		N.A.  LDD0221  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [1]
 LDCM0107  IAA HeLa N.A.  LDD0221  [1]

References

1 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.