Details of the Target

General Information of Target

Target ID LDTP17358
Target Name Choriogonadotropin subunit beta variant 2 (CGB2)
Gene Name CGB2
Gene ID 114336
Synonyms
Choriogonadotropin subunit beta variant 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MNKRGKYTTLNLEEKMKVLSRIEAGRSLKSVMDEFGISKSTFYDIKKNKKLILDFVLKQD
MPLVGAEKRKRTTGAKYGDVDDAVYMWYQQKRSAGVPVRGVELQAAAERFARCFGRTDFK
ASTGWLFRFRNRHAIGNRKGCGEQVLSSVSENVEPFRQKLSMIIKEEKLCLAQLYSGDET
DLFWKSMPENSQASRKDICLPGKKINKERLSAFLCANADGTHKLKSIIIGKSKLPKSVKE
DTSTLPVIYKPSKDVWFTRELFSEWFFQNFVPEVRHFQLNVLRFHDEDVRALLLLDSCPA
HPSSESLTSEDGRIKCMFFPHNTSTLIQPMNQGVILSCKRLYRWKQLEESLVIFEESDDE
QEKGDKGVSKIKIYNIKSAIFNWAKSWEEVKQITIANAWENLLYKKEPEYDFQGLEHGDY
REILEKCGELETKLDDDRVWLNGDEEKGCLLKTKGGITKEVVQKGGEAEKQTAEFKLSAV
RESLDYLLDFVDATPEFQRFHFTLKEMQQEIVKKQFQSKIHSRIGSFLKPRPHNIKDSFS
GPSTSGSNH
Target Bioclass
Other
Family
Glycoprotein hormones subunit beta family
Subcellular location
Secreted
Uniprot ID
Q6NT52
Ensemble ID
ENST00000359342.7
HGNC ID
HGNC:16722

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C150(0.97)  LDD0078  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0020  ARS-1620 HCC44 C150(0.97)  LDD0078  [1]
 LDCM0022  KB02 ICC9 C150(0.83)  LDD2394  [2]
 LDCM0023  KB03 ICC9 C150(0.95)  LDD2811  [2]
 LDCM0024  KB05 TGBC52TKB C150(2.44)  LDD3474  [2]

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840