Details of the Target

General Information of Target

Target ID LDTP17353
Target Name Calpain-13 (CAPN13)
Gene Name CAPN13
Gene ID 92291
Synonyms
Calpain-13; EC 3.4.22.-; Calcium-activated neutral proteinase 13; CANP 13
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSTNICSFKDRCVSILCCKFCKQVLSSRGMKAVLLADTEIDLFSTDIPPTNAVDFTGRCY
FTKICKCKLKDIACLKCGNIVGYHVIVPCSSCLLSCNNRHFWMFHSQAVYDINRLDSTGV
NVLLRGNLPEIEESTDEDVLNISAEECIR
Target Bioclass
Enzyme
Family
Peptidase C2 family
Function Probable non-lysosomal thiol-protease.
Uniprot ID
Q6MZZ7
Ensemble ID
ENST00000295055.12
HGNC ID
HGNC:16663

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 SNV: p.G346Ter .
COLO792 Substitution: p.T616M .
IGR1 SNV: p.P405L .
KMCH1 SNV: p.N59S .
L428 SNV: p.D20Y .
MDAMB231 SNV: p.S270P .
MEWO SNV: p.A595V .
MFE319 SNV: p.L337P .
NCIH1944 SNV: p.W265L .
NCIH2286 SNV: p.E312Ter .
NCIH716 SNV: p.L592M .
PATU8988T SNV: p.R472Ter .
SISO SNV: p.T462I .
TOV21G SNV: p.P65T .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C297(4.33)  LDD2268  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 BRX211 C297(4.33)  LDD2268  [1]
 LDCM0023  KB03 BRX250 C28(1.84); C297(1.35)  LDD2686  [1]
 LDCM0024  KB05 BRX211 C297(1.21)  LDD3102  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840