Details of the Target
General Information of Target
| Target ID | LDTP17317 | |||||
|---|---|---|---|---|---|---|
| Target Name | Transcription factor Sp5 (SP5) | |||||
| Gene Name | SP5 | |||||
| Gene ID | 389058 | |||||
| Synonyms |
Transcription factor Sp5 |
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| 3D Structure | ||||||
| Sequence |
MELSSKKKLHALSLAEKIQVLELLDESKMSQSEVARRFQVSQPQISRICKNKEKLLADWC
SGTANRERKRKRESKYSGIDEALLCWYHIARAKAWDVTGPMLLHKAKELADIMGQDFVPS IGWLVRWKRRNNVGFGARHVLAPSFPPEPPPPGLTSQAQLPLSLKDFSPEDVFGCAELPL LYRAVPGSFGACDQVQVLLCANSRGTEKRRVLLGGLQAAPRCFFGIRSEALPASYHPDLG IPWLEWLAQFDRDMGQQGRQVALLLAARVVEELAGLPGLYHVKLLPLAASSTTPPLPSSV VRAFKAHYRHRLLGKLAAIQSERDGTSLAEAGAGITVLDALHVASAAWAKVPPQLIFSSF IQEGLAPGKTPPSSHKTSEMPPVPGGLSLEEFSRFVDLEGEEPRSGVCKEEIGTEDEKGD REGAFEPLPTKADALRALGTLRRWFECNSTSPELFEKFYDCEEEVERLCCL |
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| Target Bioclass |
Transcription factor
|
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| Family |
Sp1 C2H2-type zinc-finger protein family
|
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| Subcellular location |
Nucleus
|
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| Function | Binds to GC boxes promoters elements. Probable transcriptional activator that has a role in the coordination of changes in transcription required to generate pattern in the developing embryo. | |||||
| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
|
ONAyne Probe Info |
 |
K391(3.85) | LDD0274 | [1] | |
|
IPM Probe Info |
 |
N.A. | LDD0241 | [2] | |
|
BTD Probe Info |
 |
C40(0.63) | LDD1700 | [3] | |
Competitor(s) Related to This Target
| Competitor ID | Name | Cell line | Binding Site(Ratio) | Interaction ID | Ref |
|---|---|---|---|---|---|
| LDCM0213 | Electrophilic fragment 2 | MDA-MB-231 | C40(1.25) | LDD1702 | [3] |
| LDCM0023 | KB03 | MDA-MB-231 | C40(1.71) | LDD1701 | [3] |
| LDCM0506 | Nucleophilic fragment 16a | MDA-MB-231 | C40(0.67) | LDD2099 | [3] |
| LDCM0516 | Nucleophilic fragment 21a | MDA-MB-231 | C40(0.56) | LDD2109 | [3] |
| LDCM0530 | Nucleophilic fragment 28a | MDA-MB-231 | C40(0.64) | LDD2123 | [3] |
| LDCM0532 | Nucleophilic fragment 29a | MDA-MB-231 | C40(1.01) | LDD2125 | [3] |
| LDCM0534 | Nucleophilic fragment 30a | MDA-MB-231 | C40(0.75) | LDD2127 | [3] |
| LDCM0211 | Nucleophilic fragment 3b | MDA-MB-231 | C40(0.63) | LDD1700 | [3] |
References