Details of the Target

General Information of Target

Target ID LDTP17315
Target Name Zinc finger protein 324B (ZNF324B)
Gene Name ZNF324B
Gene ID 388569
Synonyms
Zinc finger protein 324B
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MNALLEQKEQQERLREAAALGDIREVQKLVESGVDVNSQNEVNGWTCLHWACKRNHGQVV
SYLLKSGADKEILTTKGEMPVQLTSRREIRKIMGVEEEDDDDDDDDNLPQLKKESELPFV
PNYLANPAFPFIYTPTAEDSAQMQNGGPSTPPASPPADGSPPLLPPGEPPLLGTFPRDHT
SLALVQNGDVSAPSAILRTPESTKPGPVCQPPVSQSRSLFSSVPSKPPMSLEPQNGTYAG
PAPAFQPFFFTGAFPFNMQELVLKVRIQNPSLRENDFIEIELDRQELTYQELLRVCCCEL
GVNPDQVEKIRKLPNTLLRKDKDVARLQDFQELELVLMISENNFLFRNAASTLTERPCYN
RRASKLTY
Target Bioclass
Transcription factor
Family
Krueppel C2H2-type zinc-finger protein family
Subcellular location
Nucleus
Function May be involved in transcriptional regulation.
Uniprot ID
Q6AW86
Ensemble ID
ENST00000336614.9
HGNC ID
HGNC:33107

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
DETROIT562 SNV: p.C402Y .
HCT15 SNV: p.T336M .
HEC1 SNV: p.T476M DBIA    Probe Info 
KMS11 SNV: p.P231R .
KYSE510 SNV: p.E13K .
LS180 SNV: p.V398I .
MDAMB453 SNV: p.S81Y .
MOLT4 SNV: p.R124Q .
NCIH1703 SNV: p.A466S .
RPMI8226 SNV: p.A226V .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C198(2.56)  LDD3323  [1]
IPM
 Probe Info  		N.A.  LDD0005  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0372  CL103 HEK-293T C198(0.83)  LDD1576  [3]
 LDCM0376  CL107 HEK-293T C198(0.87)  LDD1580  [3]
 LDCM0381  CL111 HEK-293T C198(0.96)  LDD1585  [3]
 LDCM0385  CL115 HEK-293T C198(0.94)  LDD1589  [3]
 LDCM0389  CL119 HEK-293T C198(1.00)  LDD1593  [3]
 LDCM0394  CL123 HEK-293T C198(0.77)  LDD1598  [3]
 LDCM0398  CL127 HEK-293T C198(0.90)  LDD1602  [3]
 LDCM0402  CL15 HEK-293T C198(0.51)  LDD1606  [3]
 LDCM0415  CL27 HEK-293T C198(0.90)  LDD1619  [3]
 LDCM0418  CL3 HEK-293T C198(0.80)  LDD1622  [3]
 LDCM0428  CL39 HEK-293T C198(0.83)  LDD1632  [3]
 LDCM0455  CL63 HEK-293T C198(0.93)  LDD1658  [3]
 LDCM0481  CL87 HEK-293T C198(0.99)  LDD1684  [3]
 LDCM0494  CL99 HEK-293T C198(0.87)  LDD1697  [3]
 LDCM0495  E2913 HEK-293T C198(0.87)  LDD1698  [3]
 LDCM0468  Fragment33 HEK-293T C198(0.97)  LDD1671  [3]
 LDCM0022  KB02 A101D C198(2.88)  LDD2250  [1]
 LDCM0023  KB03 A101D C198(2.80)  LDD2667  [1]
 LDCM0024  KB05 SKMEL24 C198(2.56)  LDD3323  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
3 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402