Details of the Target

General Information of Target

Target ID LDTP17306
Target Name Protein sel-1 homolog 3 (SEL1L3)
Gene Name SEL1L3
Gene ID 23231
Synonyms
KIAA0746; Protein sel-1 homolog 3; Suppressor of lin-12-like protein 3; Sel-1L3
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MSFRKVNIIILVLAVALFLLVLHHNFLSLSSLLRNEVTDSGIVGPQPIDFVPNALRHAVD
GRQEEIPVVIAASEDRLGGAIAAINSIQHNTRSNVIFYIVTLNNTADHLRSWLNSDSLKS
IRYKIVNFDPKLLEGKVKEDPDQGESMKPLTFARFYLPILVPSAKKAIYMDDDVIVQGDI
LALYNTALKPGHAAAFSEDCDSASTKVVIRGAGNQYNYIGYLDYKKERIRKLSMKASTCS
FNPGVFVANLTEWKRQNITNQLEKWMKLNVEEGLYSRTLAGSITTPPLLIVFYQQHSTID
PMWNVRHLGSSAGKRYSPQFVKAAKLLHWNGHLKPWGRTASYTDVWEKWYIPDPTGKFNL
IRRYTEISNIK
Target Bioclass
Other
Subcellular location
Membrane
Uniprot ID
Q68CR1
Ensemble ID
ENST00000264868.9
HGNC ID
HGNC:29108

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AN3CA Deletion: p.R131GfsTer15 .
HEC1B SNV: p.Y420H .
HSC4 SNV: p.I878M .
HT115 SNV: p.R94C .
IGROV1 Insertion: p.G374WfsTer13 .
L428 Insertion: p.N989Ter
SNV: p.S908P		 .
LNCaP clone FGC SNV: p.Y569C; p.N883D .
LS123 SNV: p.L1053F .
LUDLU1 SNV: p.Y575C .
MFE319 SNV: p.W716R .
MOLT4 SNV: p.R748L .
NCIH196 SNV: p.I905V .
PC14 SNV: p.L519M .
PC9 SNV: p.L519M .
PF382 SNV: p.R357Ter .
RPMI8226 SNV: p.R26W .
SAOS2 SNV: p.H552Q .
VCAP SNV: p.V877A .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C87(1.94)  LDD3312  [1]
Acrolein
 Probe Info  		N.A.  LDD0227  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0161  [3]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STS-1
 Probe Info  		N.A.  LDD0136  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 ICC10 C931(1.75)  LDD2379  [1]
 LDCM0023  KB03 ICC13-7 C931(3.71)  LDD2801  [1]
 LDCM0024  KB05 HMCB C87(1.94)  LDD3312  [1]
 LDCM0109  NEM HeLa N.A.  LDD0227  [2]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
4 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.