Details of the Target

General Information of Target

Target ID LDTP17300
Target Name Solute carrier family 22 member 10 (SLC22A10)
Gene Name SLC22A10
Gene ID 387775
Synonyms
OAT5; Solute carrier family 22 member 10; Organic anion transporter 5
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MASSQGKNELKLADWMATLPESMHSIPLTNLAIPGSHDSFSFYIDEASPVGPEQPETVQN
FVSVFGTVAKKLMRKWLATQTMNFTGQLGAGIRYFDLRISTKPRDPDNELYFAHGLFSAK
VNEGLEEINAFLTDHHKEVVFLDFNHFYGMQKYHHEKLVQMLKDIYGNKMCPAIFAQEVS
LKYLWEKDYQVLVFYHSPVALEVPFLWPGQMMPAPWANTTDPEKLIQFLQASITERRKKG
SFFISQVVLTPKASTVVKGVASGLRETITERALPAMMQWVRTQKPGESGINIVTADFVEL
GDFISTVIKLNYVFDEGEANT
Target Bioclass
Transporter and channel
Family
Major facilitator (TC 2.A.1) superfamily, Organic cation transporter (TC 2.A.1.19) family
Subcellular location
Membrane
Uniprot ID
Q63ZE4
Ensemble ID
ENST00000332793.11
HGNC ID
HGNC:18057

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
COLO792 SNV: p.P344L .
HCC1395 SNV: p.E69K .
HCT15 SNV: p.E327D .
HT SNV: p.Y126H; p.T188I .
JM1 SNV: p.N82T .
MCC13 SNV: p.P115L .
MFE319 SNV: p.T462A .
NCIH1793 SNV: p.A422D .
NCIH2286 SNV: p.A303P; p.Q409H .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IA-alkyne
 Probe Info  		N.A.  LDD0161  [1]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Approved
Click To Hide/Show 3 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Conjugated Estrogens Small molecular drug DB00286
Probenecid Small molecular drug DB01032
Salicylic Acid Small molecular drug DB00936

References

1 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060