Details of the Target

General Information of Target

Target ID LDTP17293
Target Name LysM and putative peptidoglycan-binding domain-containing protein 4 (LYSMD4)
Gene Name LYSMD4
Gene ID 145748
Synonyms
LysM and putative peptidoglycan-binding domain-containing protein 4
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAVDVEFGVAGWWEAAAPLSPSAVAATFTETWPGSERAEPGRIQHPLWPGSSEGLQLLVC
FLLLNSCPGGCSDTSAHDGQDQVGVGQLWPLQGFATPVFQHLQVVLQQIIPQGLFWKDDI
TQDAMIQKMEHASRLHPQEPCLKDGKALFPTKTTESPLAKVNRDQCFTSEVVSKALKQEV
ANPVKITYRCSYGGLDMMQAPGPSKEEIIYKIMRLLWATSYCGPQPCG
Target Bioclass
Other
Subcellular location
Membrane
Uniprot ID
Q5XG99
Ensemble ID
ENST00000344791.6
HGNC ID
HGNC:26571

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
DU145 SNV: p.L201I; p.P249L .
JHH7 SNV: p.F240L .
LNCaP clone FGC SNV: p.R76W .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C93(2.21)  LDD3380  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HEK-293T C93(0.96)  LDD1508  [2]
 LDCM0226  AC11 HEK-293T C93(1.02)  LDD1509  [2]
 LDCM0277  AC18 HEK-293T C93(1.00)  LDD1516  [2]
 LDCM0278  AC19 HEK-293T C93(1.04)  LDD1517  [2]
 LDCM0279  AC2 HEK-293T C93(0.99)  LDD1518  [2]
 LDCM0286  AC26 HEK-293T C93(1.02)  LDD1525  [2]
 LDCM0287  AC27 HEK-293T C93(0.91)  LDD1526  [2]
 LDCM0290  AC3 HEK-293T C93(1.04)  LDD1529  [2]
 LDCM0295  AC34 HEK-293T C93(1.00)  LDD1534  [2]
 LDCM0296  AC35 HEK-293T C93(0.99)  LDD1535  [2]
 LDCM0304  AC42 HEK-293T C93(1.00)  LDD1543  [2]
 LDCM0305  AC43 HEK-293T C93(0.99)  LDD1544  [2]
 LDCM0313  AC50 HEK-293T C93(0.91)  LDD1552  [2]
 LDCM0314  AC51 HEK-293T C93(1.01)  LDD1553  [2]
 LDCM0321  AC58 HEK-293T C93(1.03)  LDD1560  [2]
 LDCM0322  AC59 HEK-293T C93(1.00)  LDD1561  [2]
 LDCM0405  CL18 HEK-293T C93(0.98)  LDD1609  [2]
 LDCM0406  CL19 HEK-293T C93(0.98)  LDD1610  [2]
 LDCM0419  CL30 HEK-293T C93(0.98)  LDD1623  [2]
 LDCM0420  CL31 HEK-293T C93(0.87)  LDD1624  [2]
 LDCM0432  CL42 HEK-293T C93(0.98)  LDD1636  [2]
 LDCM0433  CL43 HEK-293T C93(0.94)  LDD1637  [2]
 LDCM0445  CL54 HEK-293T C93(0.86)  LDD1648  [2]
 LDCM0446  CL55 HEK-293T C93(0.94)  LDD1649  [2]
 LDCM0451  CL6 HEK-293T C93(0.97)  LDD1654  [2]
 LDCM0458  CL66 HEK-293T C93(1.00)  LDD1661  [2]
 LDCM0459  CL67 HEK-293T C93(1.04)  LDD1662  [2]
 LDCM0462  CL7 HEK-293T C93(1.05)  LDD1665  [2]
 LDCM0471  CL78 HEK-293T C93(0.97)  LDD1674  [2]
 LDCM0472  CL79 HEK-293T C93(0.97)  LDD1675  [2]
 LDCM0485  CL90 HEK-293T C93(0.89)  LDD1688  [2]
 LDCM0486  CL91 HEK-293T C93(1.09)  LDD1689  [2]
 LDCM0022  KB02 A2780 C93(1.52)  LDD2254  [1]
 LDCM0023  KB03 A2780 C93(2.13)  LDD2671  [1]
 LDCM0024  KB05 OV-90 C93(2.21)  LDD3380  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402