Details of the Target

General Information of Target

Target ID LDTP17270
Target Name Divergent protein kinase domain 1B (DIPK1B)
Gene Name DIPK1B
Gene ID 138311
Synonyms
C9orf136; FAM69B; Divergent protein kinase domain 1B; Protein FAM69B
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTGCPASSRRRGFGLFFFLRLHRLLLLFLVLRGTLANKLNVPQVLLPFGREPGRVPFLLE
AQRGCYTWHSTHHDAVTVEPLYENGTLCSQKAVLIAESTQPIRLSSIILAREIVTDHELR
CDVKVDVINSIEIVSRARELYVDDSPLELMVRALDAEGNTFSSLAGMMFEWSIAQDNESA
REELSSKIRILKYSEAEYAPPIYIAEMEKEEKQGDVILVSGIRTGAAVVKVRIHEPFYKK
VAAALIRLLVLENIFLIPSHDIYLLVGTYIKYQVAKMVQGRVTEVKFPLEHYILELQDHR
VALNGSHSEKVAILDDKTAMVTASQLGQTNLVFVHKNVHMRSVSGLPNCTIYVVEPGFLG
FTVQPGNRWSLEVGQVYVITVDVFDKSSTKVYISDNLRITYDFPKEYFEEQLTTVNGSYH
IVKALKDGVVVINASLTSIIYQNKDIQPIKFLIKHQQEVKIYFPIMLTPKFLAFPHHPMG
MLYRYKVQVEGGSGNFTWTSSNETVVIVTTKGVVTAGQVRGNSTVLARDVQNPFRYGEIK
IHVLKLNKMELLPFHADVEIGQIIEIPIAMYHINKETKEAMAFTDCSHLSLDLNMDKQGV
FTLLKEGIQRPGPMHCSSTHIAAKSLGHTLVTVSVNECDKYLESSATFAAYEPLKALNPV
EVALVTWQSVKEMVFEGGPRPWILEPSRFFLELNAEKTEKIGIAQVWLPSKRKQNQYIYR
IQCLDLGEQVLTFRIGNHPGVLNPSPAVEVLQVRFICAHPASMSVTPVYKVPAGAQPCPL
PQHNKWLIPVSRLRDTVLELAVFDQHRRKFDNFSSLMLEWKSSNETLAHFEDYKSVEMVA
KDDGSGQTRLHGHQILKVHQIKGTVLIGVNFVGYSEKKSPKEISNLPRSVDVELLLVDDV
TVVPENATIYNHPDVKETFSLVEGSGYFLVNSSEQGVVTITYMEAESSVELVPLHPGFFT
LEVYDLCLAFLGPATAHLRVSDIQELELDLIDKVEIDKTVLVTVRVLGSSKRPFQNKYFR
NMELKLQLASAIVTLTPMEQQDEYSENYILRATTIGQTTLVAIAKDKMGRKYTSTPRHIE
VFPPFRLLPEKMTLIPMNMMQVMSEGGPQPQSIVHFSISNQTVAVVNRRGQVTGKIVGTA
VVHGTIQTVNEDTGKVIVFSQDEVQIEVVQLRAVRILAAATRLITATKMPVYVMGVTSTQ
TPFSFSNANPGLTFHWSMSKRDVLDLVPRHSEVFLQLPVEHNFAMVVHTKAAGRTSIKVT
VHCMNSSSGQFEGNLLELSDEVQILVFEKLQLFYPECQPEQILMPINSQLKLHTNREGAA
FVSSRVLKCFPNSSVIEEDGEGLLKAGSIAGTAVLEVTSIEPFGVNQTTITGVQVAPVTY
LRVSSQPKLYTAQGRTLSAFPLGMSLTFTVQFYNSIGEKFHTHNTQLYLALNRDDLLHIG
PGNKNYTYMAQAVNRGLTLVGLWDRRHPGMADYIPVAVEHAIEPDTKLTFVGDIICFSTH
LVSQHGEPGIWMISANNILQTDIVTGVGVARSPGTAMIFHDIPGVVKTYREVVVNASSRL
MLSYDLKTYLTNTLNSTVFKLFITTGRNGVNLKGFCTPNQALAITKVLLPATLMLCHVQF
SNTLLDIPASKVFQVHSDFSMEKGVYVCIIKVRPQSEELLQALSVADTSVYGWATLVSER
SKNGMQRILIPFIPAFYINQSELVLSHKQDIGEIRVLGVDRVLRKLEVISSSPVLVVAGH
SHSPLTPGLAIYSVRVVNFTSFQQMASPVFINISCVLTSQSEAVVVRAMKDKLGADHCED
SAILKRFTGSYQILLLTLFAVLASTASIFLAYNAFLNKIQTVPVVYVPTLGTPQPGFFNS
TSSPPHFMSLQPPLAQSRLQHWLWSIRH
Target Bioclass
Other
Family
DIPK family
Subcellular location
Endoplasmic reticulum membrane
Uniprot ID
Q5VUD6
Ensemble ID
ENST00000371691.5
HGNC ID
HGNC:28290

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CORL88 Deletion: p.Q356RfsTer77 .
HCC1419 Substitution: p.R30C .
HCT15 SNV: p.G100D .
HT115 SNV: p.S52P .
Ishikawa (Heraklio) 02 ER SNV: p.L4Q .
KU1919 SNV: p.A243T .
LNCaP clone FGC SNV: p.L361F .
MELJUSO SNV: p.P266A .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C334(1.09)  LDD1575  [1]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [2]
IPM
 Probe Info  		C334(0.00); C396(0.00); C14(0.00)  LDD2156  [3]
AOyne
 Probe Info  		12.90  LDD0443  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0371  CL102 HEK-293T C334(1.09)  LDD1575  [1]
 LDCM0375  CL106 HEK-293T C334(1.09)  LDD1579  [1]
 LDCM0380  CL110 HEK-293T C334(1.15)  LDD1584  [1]
 LDCM0384  CL114 HEK-293T C334(1.43)  LDD1588  [1]
 LDCM0388  CL118 HEK-293T C334(1.05)  LDD1592  [1]
 LDCM0393  CL122 HEK-293T C334(1.04)  LDD1597  [1]
 LDCM0397  CL126 HEK-293T C334(1.50)  LDD1601  [1]
 LDCM0401  CL14 HEK-293T C334(1.18)  LDD1605  [1]
 LDCM0407  CL2 HEK-293T C334(1.00)  LDD1611  [1]
 LDCM0414  CL26 HEK-293T C334(1.05)  LDD1618  [1]
 LDCM0441  CL50 HEK-293T C334(1.29)  LDD1645  [1]
 LDCM0454  CL62 HEK-293T C334(1.04)  LDD1657  [1]
 LDCM0467  CL74 HEK-293T C334(0.99)  LDD1670  [1]
 LDCM0480  CL86 HEK-293T C334(0.89)  LDD1683  [1]
 LDCM0493  CL98 HEK-293T C334(1.56)  LDD1696  [1]
 LDCM0427  Fragment51 HEK-293T C334(1.00)  LDD1631  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Diamine acetyltransferase 1 (SAT1) Acetyltransferase family P21673

References

1 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
2 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
3 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
4 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.