Details of the Target

General Information of Target

Target ID LDTP17265
Target Name Kelch domain-containing protein 7A (KLHDC7A)
Gene Name KLHDC7A
Gene ID 127707
Synonyms
Kelch domain-containing protein 7A
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MATNYSANQYEKAFSSKYLQNWSPTKPTKESISSHEGYTQIIANDRGHLLPSVPRSKANP
WGSFMGTWQMPLKIPPARVTLTSRTTAGAASLTKWIQKNPDLLKASNGLCPEILGKPHDP
DSQKKLRKKSITKTVQQARSPTIIPSSPAANLNSPDELQSSHPSAGHTPGPQRPAKS
Target Bioclass
Other
Subcellular location
Membrane
Uniprot ID
Q5VTJ3
Ensemble ID
ENST00000400664.3
HGNC ID
HGNC:26791

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C389(2.59); C500(1.42); C474(2.34)  LDD3314  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 786-O C500(1.92)  LDD2247  [1]
 LDCM0023  KB03 786-O C500(2.16)  LDD2664  [1]
 LDCM0024  KB05 IGR37 C389(2.59); C500(1.42); C474(2.34)  LDD3314  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840