Details of the Target

General Information of Target

Target ID LDTP17262
Target Name Annexin A8-like protein 1 (ANXA8L1)
Gene Name ANXA8L1
Gene ID 728113
Synonyms
ANXA8L2; Annexin A8-like protein 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MARRRRRACIALFLVLLFAFGTLMGLRTLKAPDGLPALGPGLELAPFERRPEGAPAPAAR
APAAPAAPPPPPPPPRTADPGGSPGPAPAEAEPAPVQSLRVYSDLHAFYYSWYGSPRREG
HYIHWDHVMVPHWDPKISASYPRGRHSPPDDLGSSFYPELGPYSSRDPEVLREHMTQLKE
AAIGVLVLSWYPPGMADDNGEPSDDLVPAILDTAHQYSIQVAFHIQPYKGRDDITVHDNI
KYIIDTYGSHGAFYRYKNSMGKSLPLFYIYDSYLTSPEAWAHLLTPNGPHSIRNTPYDGV
FIALLVEEGHTHDILAAGFDGMYTYFASNGFSFGSSHQNWKAVKNFCDANNLMFIPSVGP
GYIDTSIRPWNNHNTRNRVNGKYYETALQAALTVRPEIVSITSFNEWHEGTQIEKAIPKK
TPTRLYLDYLPHQPSLYLELTRRWAEHFIKEKEQWLM
Target Bioclass
Other
Family
Annexin family
Uniprot ID
Q5VT79
Ensemble ID
ENST00000619162.5
HGNC ID
HGNC:23334

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C99(1.47)  LDD3331  [1]
HHS-475
 Probe Info  		Y263(0.78); Y264(1.06)  LDD0264  [2]
HHS-465
 Probe Info  		Y263(1.89); Y264(8.53)  LDD2237  [3]
Acrolein
 Probe Info  		C161(0.00); C206(0.00)  LDD0221  [4]
IA-alkyne
 Probe Info  		C250(0.00); C206(0.00); C161(0.00)  LDD0162  [5]
Methacrolein
 Probe Info  		N.A.  LDD0218  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0108  Chloroacetamide HeLa C161(0.00); C206(0.00)  LDD0222  [4]
 LDCM0116  HHS-0101 DM93 Y263(0.78); Y264(1.06)  LDD0264  [2]
 LDCM0117  HHS-0201 DM93 Y263(0.84); Y264(0.95)  LDD0265  [2]
 LDCM0118  HHS-0301 DM93 Y263(0.81); Y264(0.97)  LDD0266  [2]
 LDCM0119  HHS-0401 DM93 Y263(0.82); Y264(1.11)  LDD0267  [2]
 LDCM0120  HHS-0701 DM93 Y263(0.91); Y264(1.13)  LDD0268  [2]
 LDCM0107  IAA HeLa C161(0.00); C206(0.00)  LDD0221  [4]
 LDCM0022  KB02 BxPC-3 C99(2.00)  LDD2280  [1]
 LDCM0023  KB03 AN3-CA C99(1.59)  LDD2681  [1]
 LDCM0024  KB05 MKN-1 C99(1.47)  LDD3331  [1]
 LDCM0109  NEM HeLa C206(0.00); C161(0.00)  LDD0224  [4]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
3 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
4 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
5 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060