Details of the Target

General Information of Target

Target ID LDTP17206
Target Name Glutamate-rich protein 3 (ERICH3)
Gene Name ERICH3
Gene ID 127254
Synonyms
C1orf173; Glutamate-rich protein 3
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEKFRAVLDLHVKHHSALGYGLVTLLTAGGERIFSAVAFQCPCSAAWNLPYGLVFLLVPA
LALFLLGYVLSARTWRLLTGCCSSARASCGSALRGSLVCTQISAAAALAPLTWVAVALLG
GAFYECAATGSAAFAQRLCLGRNRSCAAELPLVPCNQAKASDVQDLLKDLKAQSQVLGWI
LIAVVIIILLIFTSVTRCLSPVSFLQLKFWKIYLEQEQQILKSKATEHATELAKENIKCF
FEGSHPKEYNTPSMKEWQQISSLYTFNPKGQYYSMLHKYVNRKEKTHSIRSTEGDTVIPV
LGFVDSSGINSTPEL
Target Bioclass
Other
Uniprot ID
Q5RHP9
Ensemble ID
ENST00000326665.10
HGNC ID
HGNC:25346

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A375 SNV: p.W812Ter .
AGS SNV: p.T109K; p.D563N .
BT549 Deletion: p.S477RfsTer14 .
C32 SNV: p.P1488L .
CCK81 Deletion: p.D536IfsTer3 .
DU145 SNV: p.A933D .
HCC44 SNV: p.M959I .
HCT15 SNV: p.D952A .
HEC1 SNV: p.P1230L .
HEC1B SNV: p.P1230L .
HS936T SNV: p.S185F .
HT SNV: p.E1413A .
HT115 SNV: p.F352C .
IGR1 SNV: p.G158E; p.D961N .
IGROV1 SNV: p.L870P .
IPC298 SNV: p.P199S; p.R371W .
KMS27 SNV: p.K715R .
KYSE150 SNV: p.T463I .
LN229 SNV: p.H20Y .
LNCaP clone FGC SNV: p.A1100T .
LS180 SNV: p.R829K .
MCC26 SNV: p.G841Ter .
MELHO SNV: p.P1155S .
MELJUSO SNV: p.G672R .
MEWO SNV: p.E67K; p.R259C; p.G510D; p.K965M; p.E1104K .
NALM6 SNV: p.R110I .
NCIH146 SNV: p.S349T; p.R371W .
NCIH1993 SNV: p.E1043Ter .
NCIH661 SNV: p.L95S .
OPM2 SNV: p.S693P .
RL952 SNV: p.V1423A .
SKMEL24 SNV: p.P239S .
SKN SNV: p.A780V .
SNU1 SNV: p.V1405A .
TE11 SNV: p.E613Ter .
YSCCC SNV: p.H75Y; p.D303E .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C509(1.24)  LDD3372  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 HG-3 C509(1.77); C560(1.14)  LDD2355  [1]
 LDCM0023  KB03 HG-3 C560(1.10)  LDD2772  [1]
 LDCM0024  KB05 OCI-Ly3 C509(1.24)  LDD3372  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840