Details of the Target

General Information of Target

Target ID LDTP17197
Target Name Calcium homeostasis modulator protein 4 (CALHM4)
Gene Name CALHM4
Gene ID 221301
Synonyms
C6orf78; FAM26D; Calcium homeostasis modulator protein 4; Protein FAM26D
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGPLQFRDVAIEFSLEEWHCLDAAQRNLYRDVMLENYRNLIFLGIVVSKPNLITCLEQGK
KPLTMKRHEMIAKPPVMYSHFAQDLWSEQSIKDSFQKVILRRYEKCRHDNLQLKKGCESV
DECPVHKRGYNGLKQCLATTQRKIFQCDEYVKFLHKFSNSNKHKIRDTGKKSFKCIEYGK
TFNQSSTRTTYKKIDAGEKRYKCEECGKAYKQSSHLTTHKKIHTGEKPYKCEECGKAYKQ
SCNLTTHKIIHTGEKPYRCRECGKAFNHPATLFSHKKIHTGEKPYKCDKCGKAFISSSTL
TKHEIIHTGEKPYKCEECGKAFNRSSNLTKHKRIHTGDVPYKCDECGKTFTWYSSLSKHK
RAHTGEKPYKCEECGKAFTAFSTLTEHKIIHTGEKPYKCEECGKAFNWSSALNKHKKIHI
RQKPCIVKNVENLLNVPQPLISIR
Target Bioclass
Transporter and channel
Family
CALHM family
Subcellular location
Membrane
Function Pore-forming subunit of a voltage-gated ion channel.
Uniprot ID
Q5JW98
Ensemble ID
ENST00000368596.4
HGNC ID
HGNC:21094

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
MDAMB468 SNV: p.N7S .
NCIH1993 SNV: p.C269R .
TC71 SNV: p.P143T .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IA-alkyne
 Probe Info  		N.A.  LDD0161  [1]

References

1 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060