Details of the Target

General Information of Target

Target ID LDTP17189
Target Name NHL repeat-containing protein 3 (NHLRC3)
Gene Name NHLRC3
Gene ID 387921
Synonyms
NHL repeat-containing protein 3
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MHQSLTQQRSSDMSLPDSMGAFNRRKRNSIYVTVTLLIVSVLILTVGLAATTRTQNVTVG
GYYPGVILGFGSFLGIIGSNLIENKRQMLVASIVFISFGVIAAFCCAIVDGVFAARHIDL
KPLYANRCHYVPKTSQKEAEEVISSSTKNSPSTRVMRNLTQAAREVNCPHLSREFCTPRI
RGNTCFCCDLYNCGNRVEITGGYYEYIDVSSCQDIIHLYHLLWSATILNIVGLFLGIITA
AVLGGFKDMNPTLPALNCSVENTHPTVSYYAHPQVASYNTYYHSPPHLPPYSAYDFQHSG
VFPSSPPSGLSDEPQSASPSPSYMWSSSAPPRYSPPYYPPFEKPPPYSP
Target Bioclass
Enzyme
Subcellular location
Secreted
Uniprot ID
Q5JS37
Ensemble ID
ENST00000379599.6
HGNC ID
HGNC:33751

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CAL78 Deletion: p.L45FfsTer33 .
HEC1B SNV: p.R264M .
LNCaP clone FGC SNV: p.V68F .
SKN Deletion: p.L200FfsTer49 .
SUPT1 SNV: p.G109C .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IA-alkyne
 Probe Info  		N.A.  LDD0036  [1]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [1]

References

1 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853