Details of the Target

General Information of Target

Target ID LDTP17174
Target Name Armadillo repeat-containing X-linked protein 4 (ARMCX4)
Gene Name ARMCX4
Gene ID 100131755
Synonyms
Armadillo repeat-containing X-linked protein 4
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MESEYVLCNWKDQLWPAKVLSRSETSSNSKRKKAFSLEVQILSLDEKIKLDSTETKILNK
SQIEAIAASLGLQSEDSAPPTEETAYGRSLKVALGILNERTNLSQASTSDEEEITMLSQN
VPQKQSDSPPHKKYRKDEGDLPGCLEERENSACLLASSESDDSLYDDKSQAPTMVDTIPS
EVETKSLQNSSWCETFPSLSEDNDEKENKNKIDISAVMSVHSAVKEESACVKDEKFAPPL
SPLSSDMLIMPKALKEESEDTCLETLAVPSECSAFSENIEDPGEGPSNPCLDTSQNQPSM
ESEMGAAACPGSCSRECEVSFSASNPVWDYSHLMSSERNFQRLDFEELEEEGQASDKSLL
PSRINLSLLDDDEEDEELPRFILHYETHPFETGMIVWFKYQKYPFWPAVIKSIRRKERKA
SVLFVEANMNSEKKGIRVNFRRLKKFDCKEKQMLVDKAREDYSESIDWCISLICDYRVRI
GCGSFTGSLLEYYAADISYPVRKETKQDTFRNKFPKLHNEDAREPMAVTSQTKKMSFQKI
LPDRMKAARDRANKNLVDFIVNAKGTENHLLAIVNGTKGSRWLKSFLNANRFTPCIETYF
EDEDQLDEVVKYLQEVCNQIDQIMPTWIKDDKIKFILEVLLPEAIICSISAVDGLDYEAA
EAKYLKGPCLGYRERELFDAKIIYEKRRKAPTNEAH
Target Bioclass
Other
Family
Eutherian X-chromosome-specific Armcx family
Subcellular location
Membrane
Uniprot ID
Q5H9R4
Ensemble ID
ENST00000423738.5
HGNC ID
HGNC:28615

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A498 SNV: p.P334H .
AGS SNV: p.E2273G .
AN3CA SNV: p.A1357T .
DU145 SNV: p.K509M .
HCT15 SNV: p.A1155V .
IGR37 SNV: p.G1214W DBIA    Probe Info 
KU1919 SNV: p.A1821D .
KYSE30 SNV: p.S907F .
LN18 SNV: p.G1268E .
LOXIMVI SNV: p.R2268Ter .
MCC13 SNV: p.G1537E .
MCC26 SNV: p.G570S .
MFE319 SNV: p.S319Y .
MONOMAC6 SNV: p.G1300C .
NCIH1703 SNV: p.R140G .
NCIH2286 SNV: p.R565M .
NCIH358 SNV: p.Q1395H .
NCIH446 SNV: p.M2196I .
OVCAR5 SNV: p.T123K .
RKO SNV: p.A2269V .
SNGM SNV: p.P1650H .
SNU423 Deletion: p.H613IfsTer332 .
SSP25 SNV: p.R1152W .
SW756 SNV: p.W1647C .
TGBC1TKB SNV: p.G1411E .
THP1 SNV: p.T1999A .
WM2664 Insertion: p.A91GfsTer26 .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C279(1.93)  LDD3310  [1]
IA-alkyne
 Probe Info  		N.A.  LDD0161  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 G-361 C279(2.68)  LDD2329  [1]
 LDCM0023  KB03 G-361 C279(2.09)  LDD2746  [1]
 LDCM0024  KB05 COLO792 C279(1.93)  LDD3310  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Kallikrein-6 (KLK6) Peptidase S1 family Q92876

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060