Details of the Target

General Information of Target

Target ID LDTP17160
Target Name Putative heat shock protein HSP 90-alpha A5 (HSP90AA5P)
Gene Name HSP90AA5P
Synonyms
HSP90AE; Putative heat shock protein HSP 90-alpha A5; Heat shock protein 90-alpha E; Heat shock protein 90Ae
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSLIINTFYSNKEIFLQELISNASDALDKIRYESLTDPSKLDGGKELKIDIIPNPRECIL
TLVNTGIGMTKADLINNLGAIAKSGTEAFMEAFQSCAEISMIGQFGVGFYSAYLVAEKVA
ITKHNDEEQYSWVSSAGSSFTLHVDHGEPIDRDTKVILHLKEDQTEYLEERWVKEVVKKH
PQFIGCLIAVYLEKEPEKEISDDEEEKGEKEEEDKDDKEKPKTEDVGSDEEDDTDKNNKK
KTKKIKEKYTDREELNQTKPIWTRNPDDITQEECGEFYKSLTSAWEDHLAVKQFPVEEQE
ENEQLCVHHVWIMDSFDDLMPEYVGFVREDKENNKKLDEVFSKISWLGIHEDSINWRHLS
ELLWSHTFQSGDEMTSLSEYVSCMKEAQKSICDIIGECKEQVANSAFVEQEWKKGFEVIY
MSEPIDEYCVQQLKEFDGKSLLSVTKEGLELPEDEEEKKIMEESNVKFENLCRLMKEILD
KKVERVTISSRLVSSPCRIVTSTYS
Target Bioclass
Other
Family
Heat shock protein 90 family
Subcellular location
Cytoplasm
Function Putative molecular chaperone that may promote the maturation, structural maintenance and proper regulation of specific target proteins.
Uniprot ID
Q58FG0
HGNC ID
HGNC:32535

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
AZ-9
 Probe Info  		E182(0.89); E242(1.02); K184(0.79)  LDD2208  [1]
DBIA
 Probe Info  		C694(4.13)  LDD3314  [2]
HHS-475
 Probe Info  		Y177(1.04)  LDD0264  [3]
HHS-465
 Probe Info  		Y177(9.00); Y178(8.16); Y46(7.21)  LDD2237  [4]
IA-alkyne
 Probe Info  		N.A.  LDD0161  [5]
IPIAA_H
 Probe Info  		N.A.  LDD0030  [6]
NAIA_5
 Probe Info  		N.A.  LDD2223  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0116  HHS-0101 DM93 Y177(1.04)  LDD0264  [3]
 LDCM0117  HHS-0201 DM93 Y177(0.94)  LDD0265  [3]
 LDCM0118  HHS-0301 DM93 Y177(0.80)  LDD0266  [3]
 LDCM0119  HHS-0401 DM93 Y177(0.85)  LDD0267  [3]
 LDCM0120  HHS-0701 DM93 Y177(0.66)  LDD0268  [3]
 LDCM0022  KB02 A204 C694(2.37)  LDD2252  [2]
 LDCM0023  KB03 A204 C694(2.76)  LDD2669  [2]
 LDCM0024  KB05 IGR37 C694(4.13)  LDD3314  [2]

References

1 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
4 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
5 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
6 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
7 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264