Details of the Target | Chem(Pro)²

General Information of Target

Target ID	LDTP17135
Target Name	Heat shock factor protein 5 (HSF5)
Gene Name	HSF5
Gene ID	124535
Synonyms	HSTF5; Heat shock factor protein 5; HSF 5; Heat shock transcription factor 5; HSTF 5
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MSNLKMKEAALIYLDRSGGLQKFIDDCKYYNDSKQSYAVYRFKILINPSDVVELDAELGN HILHQPLKAAEVFQSVCFIAVKTLSLIGQLQTETQINIVLKLTHLPPLPSYGLDLCEFPL DYTSQRFYMMQGIVIAMTTITKYTQGARFLCSDEACPLSKGFQYIRVHVPGATESATIRN DFLCNLCASSLQEDRKFRVLGDKQIVEIIATKALRAFQGYSNNQPFRFQSLTIFLRDESV NKMNIGNEYKIIGIPTCVKTSQTAVCIEANSITFCNSKVPSGISDNFRCLLSLTSSSCWK FTAILANIFASQITPPGTYNLLKLCLLMSLVQTTDRNKELEDCLDILIITSDTLLIDRLL NFSINLVPRGIRHLVSTEIFPTLSRNKYGTGAVSIQAGSALLAKGGICFIGDLASHKKDK LEQLQTVLESRSITVYIPGKKFGEDIDQQMTFPVQCSFWSFVDVDSSSRRNAQKINTLIG QMDCSLIPANLVEAFGLLINCNESSPCHPFLPTVQHTLNKAINPEGLFYAASRQFTTEDF EKLLAFAKNLNVEFSLEAERMTHGYYLASRRIRTGSVCGSKLSASALKYLVFLSEAHARL NLRNKVLKEDVLIAALLFETSLTLKYGATVFCVAPNAVFPFELYNEEYLEQRDLYLTQCQ QQLEQFIATYGPGTTIFSSDE
Target Bioclass	Transcription factor
Family	HSF family
Subcellular location	Nucleus
Function	May act as a transcriptional factor.
Uniprot ID	Q4G112
Ensemble ID	ENST00000323777.8
HGNC ID	HGNC:26862

Target Site Mutations in Different Cell Lines

Cell line	Mutation details			Probe for labeling this protein in this cell
A101D	SNV: p.T75S			.
AU565	SNV: p.G34S			.
DAOY	SNV: p.F111S			.
HEC1	SNV: p.R90C			.
HEC1B	SNV: p.R90C			.
HT115	SNV: p.P227H; p.Y292H			.
IGROV1	SNV: p.A165T			.
JURKAT	SNV: p.A63V			.
MOLT4	SNV: p.N12D			.
NCIH1792	SNV: p.G55V			.
NCIH716	SNV: p.G553V			.
SH4	SNV: p.E490K			.
TE8	SNV: p.Q279R			.

Probe(s) Labeling This Target

ABPP Probe

Click To Hide/Show 2 Probe Related to This Target

Probe name		Structure	Binding Site(Ratio)	Interaction ID	Ref
IA-alkyne Probe Info			C399(0.00); C261(0.00)	LDD0161	[1]
Methacrolein Probe Info			N.A.	LDD0218	[2]

References

1	SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18. Mass spectrometry data entry*: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
2	ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.