Details of the Target
General Information of Target
| Target ID | LDTP17122 | |||||
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| Target Name | Tripartite motif-containing protein 60 (TRIM60) |
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| Gene Name | TRIM60 | |||||
| Gene ID | 166655 | |||||
| Synonyms |
RNF129; RNF33; Tripartite motif-containing protein 60; RING finger protein 129; RING finger protein 33 |
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| 3D Structure | ||||||
| Sequence |
MQEELAWETDGLLPLERQLHEAARQNNVGRMQELIGRRVNTRARNHVGRVALHWAAGAGH
EQAVRLLLEHEAAVDEEDAVGALTEARLCFGMNALLLSAWFGHLRILQILVNSGAKIHCE SKDGLTLLHCAAQKGHVPVLAFIMEDLEDVALDHVDKLGRTAFHRAAEHGQLDALDFLVG SGCDHNVKDKEGNTALHLAAGRGHMAVLQRLVDIGLDLEEQNAEGLTALHSAAGGSHPDC VQLLLRAGSTVNALTQKNLSCLHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHLAVR HNFPALVRLLINSDSDVNAVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQGKTA LAVAVRSNHVSLVDMIIKADRFYRWEKDHPSDPSGKSLSFKQDHRQETQQLRSVLWRLAS RYLQPREWKKLAYSWEFTEAHVDAIEQQWTGTRSYQEHGHRMLLIWLHGVATAGENPSKA LFEGLVAIGRRDLAGWSTMARSQLTATSASRVQMILVPQPPE |
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| Target Bioclass |
Enzyme
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| Family |
TRIM/RBCC family
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| Function | E3 SUMO-protein ligase that mediates SUMOylation of TAB2 leading to inhibition of NF-kappa-B and MAPK pathways by suppressing the TRAF6/TAB2/TAK1 complex. | |||||
| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
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DBIA Probe Info |
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C59(1.42) | LDD3334 | [1] | |
Competitor(s) Related to This Target