Details of the Target

General Information of Target

Target ID LDTP17118
Target Name Archaemetzincin-1 (AMZ1)
Gene Name AMZ1
Gene ID 155185
Synonyms
KIAA1950; Archaemetzincin-1; EC 3.4.-.-; Archeobacterial metalloproteinase-like protein 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAGSVADSDAVVKLDDGHLNNSLSSPVQADVYFPRLIVPFCGHIKGGMRPGKKVLVMGIV
DLNPESFAISLTCGDSEDPPADVAIELKAVFTDRQLLRNSCISGERGEEQSAIPYFPFIP
DQPFRVEILCEHPRFRVFVDGHQLFDFYHRIQTLSAIDTIKINGDLQITKLG
Target Bioclass
Enzyme
Family
Peptidase M54 family
Function Probable zinc metalloprotease.
Uniprot ID
Q400G9
Ensemble ID
ENST00000312371.8
HGNC ID
HGNC:22231

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
KYSE150 SNV: p.D453N .
MDST8 SNV: p.D19N .
MOLT4 SNV: p.S479N .
NCIH1155 SNV: p.R273H .
RD SNV: p.C299G .
SNU1 SNV: p.A236P .
U937 SNV: p.L127P .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C131(1.68)  LDD2247  [1]
IA-alkyne
 Probe Info  		N.A.  LDD0161  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 786-O C131(1.68)  LDD2247  [1]
 LDCM0023  KB03 786-O C131(1.82)  LDD2664  [1]
 LDCM0024  KB05 KMRC-1 C131(1.74)  LDD3253  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060