Details of the Target

General Information of Target

Target ID LDTP17115
Target Name Zinc finger protein 718 (ZNF718)
Gene Name ZNF718
Gene ID 255403
Synonyms
Zinc finger protein 718
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MWRPVQLCHFHSALLHSRQKPWPSPAVFFRRNVRGLPPRFSSPTPLWRKVLSTAVVGAPL
LLGARYVMAEAREKRRMRLVVDGMGRFGRSLKVGLQISLDYWWCTNVVLRGVEENSPGYL
EVMSACHQRAADALVAGAISNGGLYVKLGQGLCSFNHLLPPEYTRTLRVLEDRALKRGFQ
EVDELFLEDFQALPHELFQEFDYQPIAAASLAQVHRAKLHDGTSVAVKVQYIDLRDRFDG
DIHTLELLLRLVEVMHPSFGFSWVLQDLKGTLAQELDFENEGRNAERCARELAHFPYVVV
PRVHWDKSSKRVLTADFCAGCKVNDVEAIRSQGLAVHDIAEKLIKAFAEQIFYTGFIHSD
PHPGNVLVRKGPDGKAELVLLDHGLYQFLEEKDRAALCQLWRAIILRDDAAMRAHAAALG
VQDYLLFAEMLMQRPVRLGQLWGSHLLSREEAAYMVDMARERFEAVMAVLRELPRPMLLV
LRNINTVRAINVALGAPVDRYFLMAKRAVRGWSRLAGATYRGVYGTSLLRHAKVVWEMLK
FEVALRLETLAMRLTALLARALVHLSLVPPAEELYQYLET
Target Bioclass
Transcription factor
Subcellular location
Nucleus
Function May be involved in transcriptional regulation.
Uniprot ID
Q3SXZ3
Ensemble ID
ENST00000510175.6
HGNC ID
HGNC:26889

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A2780 Substitution: p.K140S .
HT115 SNV: p.R471K .
HUPT4 Insertion: p.N465QfsTer6 .
ICC10 Substitution: p.K140S .
ICC106 Substitution: p.K140S .
ICC108 Substitution: p.K140S .
MEWO SNV: p.T170I .
NB1 SNV: p.M1? .
NCIH23 Substitution: p.K140S .
OE33 SNV: p.E175Ter .
ONS76 SNV: p.F320Y .
RL952 SNV: p.L43P .
SUPT1 SNV: p.V384A .
SW1271 SNV: p.H96P .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IA-alkyne
 Probe Info  		N.A.  LDD0161  [1]
HHS-465
 Probe Info  		K337(0.00); K340(0.00); Y339(0.00)  LDD2240  [2]

References

1 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
2 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010