Details of the Target

General Information of Target

Target ID LDTP17100
Target Name Prospero homeobox protein 2 (PROX2)
Gene Name PROX2
Gene ID 283571
Synonyms
Prospero homeobox protein 2; Homeobox prospero-like protein PROX2; PROX-2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSFKRPCPLARYNRTSYFYPTFSESSEHSHLLVSPVLVASAVIGVVIILSCITIIVGSIR
RDRQARLQRHRHRHHRHHHHHHHHRRRRHREYEHGYVSDEHTYSRSSRRMRYACSSSEDW
PPPLDISSDGDVDATVLRELYPDSPPGYEECVGPGATQLYVPTDAPPPYSLTDSCPTLDG
TSDSGSGHSPGRHQQEQRTPAQGGLHTVSMDTLPPYEAVCGAGPPSGLLPLPGPDPGPRG
SQGSPTPTRAPASGPERIV
Target Bioclass
Transcription factor
Family
Prospero homeodomain family
Subcellular location
Nucleus
Function Transcription regulator. Does not seem to be essential for embryonic development and postnatal survival.
Uniprot ID
Q3B8N5
Ensemble ID
ENST00000673765.1
HGNC ID
HGNC:26715

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
NAIA_4
 Probe Info  		N.A.  LDD2226  [1]

References

1 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264