Details of the Target

General Information of Target

Target ID LDTP17078
Target Name Zinc finger protein 181 (ZNF181)
Gene Name ZNF181
Gene ID 339318
Synonyms
Zinc finger protein 181; HHZ181
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MALAAAAAAAAAGVSQAAVLGFLQEHGGKVRNSELLSRFKPLLDAGDPRGRAARRDRFKQ
FVNNVAVVKELDGVKFVVLRKKPRPPEPEPAPFGPPGAAAQPSKPTSTVLPRSASAPGAP
PLVRVPRPVEPPGDLGLPTEPQDTPGGPASEPAQPPGERSADPPLPALELAQATERPSAD
AAPPPRAPSEAASPCSDPPDAEPGPGAAKGPPQQKPCMLPVRCVPAPATLRLRAEEPGLR
RQLSEEPSPRSSPLLLRRLSVEESGLGLGLGPGRSPHLRRLSRAGPRLLSPDAEELPAAP
PPSAVPLEPSEHEWLVRTAGGRWTHQLHGLLLRDRGLAAKRDFMSGFTALHWAAKSGDGE
MALQLVEVARRSGAPVDVNARSHGGYTPLHLAALHGHEDAAVLLVVRLGAQVHVRDHSGR
RAYQYLRPGSSYALRRLLGDPGLRGTTEPDATGGGSGSLAARRPVQVAATILSSTTSAFL
GVLADDLMLQDLARGLKKSSSFSKFLSASPMAPRKKTKIRGGLPAFSEISRRPTPGPLAG
LVPSLPPTT
Target Bioclass
Transcription factor
Family
Krueppel C2H2-type zinc-finger protein family
Subcellular location
Nucleus
Function May be involved in transcriptional regulation.
Uniprot ID
Q2M3W8
Ensemble ID
ENST00000459757.6
HGNC ID
HGNC:12971

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCT116 SNV: p.S389N .
HEC1 SNV: p.F274S .
HEC1B SNV: p.F433L .
IPC298 SNV: p.L532F .
JHH7 SNV: p.K202N .
MCC13 SNV: p.H427Y .
MCC26 Substitution: p.G299K .
RKO Deletion: p.R537SfsTer3 .
ZR751 SNV: p.H427Y .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
BTD
 Probe Info  		C407(0.89)  LDD2098  [1]
DBIA
 Probe Info  		C231(0.97)  LDD1492  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [3]
HHS-465
 Probe Info  		K515(0.00); K518(0.00); Y517(0.00)  LDD2240  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 HEK-293T C231(0.97)  LDD1492  [2]
 LDCM0023  KB03 Jurkat C407(10.29)  LDD0315  [3]
 LDCM0024  KB05 HEK-293T C231(0.80)  LDD1502  [2]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C407(0.89)  LDD2098  [1]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C407(0.45)  LDD2114  [1]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C407(0.89)  LDD2123  [1]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C407(1.03)  LDD2143  [1]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C407(2.68)  LDD2144  [1]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C407(1.67)  LDD2146  [1]

References

1 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
2 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
4 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010