Details of the Target

General Information of Target

Target ID LDTP17074
Target Name Protein FAM83E (FAM83E)
Gene Name FAM83E
Gene ID 54854
Synonyms
Protein FAM83E
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEPRAVGVSKQDIREQIWGYMESQNLADFPRPVHHRIPNFKGSYLACQNIKDLDVFARTQ
EVKVDPDKPLEGVRLLVLQSKKTLLVPTPRLRTGLFNKITPPPGATKDILRKCATSQGVR
NYSVPIGLDSRVLVDLVVVGSVAVSEKGWRIGKGEGYADLEYAMMVSMGAVSKETPVVTI
VHDCQVVDIPEELVEEHDITVDYILTPTRVIATGCKRPKPMGITWFKISLEMMEKIPILR
SLRAREQQAGKDVTLQGEHQHLPEPGCQQTVPLSVGRRPPDTPGPETNSMEAAPGSPPGE
GAPLAADVYVGNLPGDARVSDLKRALRELGSVPLRLTWQGPRRRAFLHYPDSAAAQQAVS
CLQGLRLGTDTLRVALARQQRDK
Target Bioclass
Other
Family
FAM83 family
Function May play a role in MAPK signaling.
Uniprot ID
Q2M2I3
Ensemble ID
ENST00000263266.4
HGNC ID
HGNC:25972

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C221(1.02)  LDD3346  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 BRX394 C221(1.18)  LDD2274  [1]
 LDCM0023  KB03 BRX401 C221(1.59)  LDD2692  [1]
 LDCM0024  KB05 NCI-H1666 C221(1.02)  LDD3346  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840