Details of the Target

General Information of Target

Target ID LDTP17058
Target Name Putative deoxyribonuclease TATDN3 (TATDN3)
Gene Name TATDN3
Gene ID 128387
Synonyms
Putative deoxyribonuclease TATDN3; EC 3.1.21.-
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGPERHLSGAPARMATVVLGGDTMGPERIFPNQTEELGHQGPSEGTGDWSSEEPEEEQEE
TGSGPAGYSYQPLNQDPEQEEVELAPVGDGDVVADIQDRIQALGLHLPDPPLESEDEDEE
GATALNNHSSIPMDPEHVELVKRTMAGVSLPAPGVPAWAREISDAQWEDVVQKALQARQA
SPAWK
Target Bioclass
Enzyme
Family
Metallo-dependent hydrolases superfamily, TatD-type hydrolase family
Subcellular location
Nucleus
Function Putative deoxyribonuclease.
Uniprot ID
Q17R31
Ensemble ID
ENST00000366973.8
HGNC ID
HGNC:27010

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
MDAMB453 SNV: p.E165K .
NCIH1155 SNV: p.S150A .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C214(0.96)  LDD1511  [1]
CY-1
 Probe Info  		Q133(0.00); Q135(0.00)  LDD0246  [2]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0281  AC21 HEK-293T C214(1.02)  LDD1520  [1]
 LDCM0289  AC29 HEK-293T C214(1.06)  LDD1528  [1]
 LDCM0298  AC37 HEK-293T C214(0.93)  LDD1537  [1]
 LDCM0307  AC45 HEK-293T C214(1.07)  LDD1546  [1]
 LDCM0312  AC5 HEK-293T C214(1.05)  LDD1551  [1]
 LDCM0316  AC53 HEK-293T C214(0.96)  LDD1555  [1]
 LDCM0325  AC61 HEK-293T C214(0.90)  LDD1564  [1]
 LDCM0248  AKOS034007472 HEK-293T C214(0.96)  LDD1511  [1]
 LDCM0409  CL21 HEK-293T C214(0.96)  LDD1613  [1]
 LDCM0422  CL33 HEK-293T C214(1.22)  LDD1626  [1]
 LDCM0435  CL45 HEK-293T C214(1.24)  LDD1639  [1]
 LDCM0448  CL57 HEK-293T C214(0.99)  LDD1651  [1]
 LDCM0461  CL69 HEK-293T C214(1.26)  LDD1664  [1]
 LDCM0475  CL81 HEK-293T C214(1.09)  LDD1678  [1]
 LDCM0484  CL9 HEK-293T C214(1.08)  LDD1687  [1]
 LDCM0488  CL93 HEK-293T C214(1.25)  LDD1691  [1]

References

1 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
2 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
3 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853