Details of the Target

General Information of Target

Target ID LDTP17020
Target Name Divergent protein kinase domain 1C (DIPK1C)
Gene Name DIPK1C
Gene ID 125704
Synonyms
C18orf51; FAM69C; Divergent protein kinase domain 1C; Protein FAM69C
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGVSKLDILYRRLLLTKLFIRGWGRPEDLKRLFEFRKMIGNRERCQNLVSSDYPVHIDKI
EEQSDCKILDGHFVSPMAHYVPDIMPIESVIARFQFIVPKEWNSKYRPVCIHLAGTGDHH
YWRRRTLMARPMIKEARMASLLLENPYYGCRKPKDQVRSSLKNVSDLFVMGGALVLESAA
LLHWLEREGYGPLGMTGISMGGHMASLAVSNWPKPMPLIPCLSWSTASGVFTTTDSFKMG
QEFVKHFTSSADKLTNLNLVSRTLNLDISNQVVSQKPADCHNSSKTSVSATSEGLLLQDT
SKMKRFNQTLSTNKSGYTSRNPQSYHLLSKEQSRNSLRKESLIFMKGVMDECTHVANFSV
PVDPSLIIVVQAKEDAYIPRTGVRSLQEIWPGCEIRYLEGGHISAYLFKQGLFR
Target Bioclass
Other
Family
DIPK family
Subcellular location
Endoplasmic reticulum membrane
Uniprot ID
Q0P6D2
Ensemble ID
ENST00000343998.8
HGNC ID
HGNC:31729

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HL60 SNV: p.L406P .
HUH7 Substitution: p.K419I .
NCIH2286 SNV: p.G139V .
SW837 SNV: p.H96P .
WM1552C SNV: p.L406P .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IA-alkyne
 Probe Info  		C278(0.14)  LDD2182  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0625  F8 Ramos C278(0.42)  LDD2187  [1]
 LDCM0573  Fragment11 Ramos C278(0.20)  LDD2190  [1]
 LDCM0576  Fragment14 Ramos C278(0.33)  LDD2193  [1]
 LDCM0566  Fragment4 Ramos C278(0.37)  LDD2184  [1]
 LDCM0569  Fragment7 Ramos C278(0.35)  LDD2186  [1]
 LDCM0022  KB02 Ramos C278(0.14)  LDD2182  [1]
 LDCM0023  KB03 Ramos C278(0.19)  LDD2183  [1]
 LDCM0024  KB05 Ramos C278(0.19)  LDD2185  [1]

References

1 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578