Details of the Target

General Information of Target

Target ID LDTP16999
Target Name Endogenous retrovirus group K member 7 Pro protein (ERVK-7)
Gene Name ERVK-7
Synonyms
Endogenous retrovirus group K member 7 Pro protein; HERV-K(III) Pro protein; HERV-K102 Pro protein; HERV-K_1q22 provirus ancestral Pro protein; EC 3.4.23.50; Protease; Proteinase; PR
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
WASQVSENRPVCKAIIQGKQFEGLVDTGADVSIIALNQWPKNWPKQKAVTGLVGIGTASE
VYQSMEILHCLGPDNQESTVQPMITSIPLNLWGRDLLQQWGAEITMPAPLYSPTSQKIMT
KRGYIPGKGLGKNEDGIKIPFEAKINQKREGIGYPF
Target Bioclass
Enzyme
Family
Peptidase A2 family, HERV class-II K(HML-2) subfamily
Function
Retroviral proteases have roles in processing of the primary translation products and the maturation of the viral particle. Endogenous Pro proteins may have kept, lost or modified their original function during evolution. This endogenous protein has retained most of the characteristics of retroviral proteases.
Uniprot ID
P63131
HGNC ID
HGNC:31828

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IA-alkyne
 Probe Info  		C207(0.00); C240(0.00); C168(0.00); C286(0.00)  LDD0161  [1]

References

1 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060