Details of the Target

General Information of Target

Target ID LDTP16967
Target Name Putative heat shock 70 kDa protein 7 (HSPA7)
Gene Name HSPA7
Synonyms
HSP70B; Putative heat shock 70 kDa protein 7; Heat shock 70 kDa protein B
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDPRECVCMSGGICMCGDNCKCTTCNCKTYWKSCCPCCPPGCAKCARGCICKGGSDKCSC
CP
Target Bioclass
Other
Family
Heat shock protein 70 family
Uniprot ID
P48741
HGNC ID
HGNC:5240

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
AZ-9
 Probe Info  		E317(1.00); D48(10.00)  LDD2208  [1]
HHS-475
 Probe Info  		Y43(0.96)  LDD0264  [2]
HHS-465
 Probe Info  		Y43(10.00)  LDD2237  [3]
IA-alkyne
 Probe Info  		C348(0.00); C27(0.00); C389(0.00); C506(0.00)  LDD0161  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0116  HHS-0101 DM93 Y43(0.96)  LDD0264  [2]
 LDCM0117  HHS-0201 DM93 Y43(0.84)  LDD0265  [2]
 LDCM0118  HHS-0301 DM93 Y43(0.85)  LDD0266  [2]
 LDCM0119  HHS-0401 DM93 Y43(0.75)  LDD0267  [2]
 LDCM0120  HHS-0701 DM93 Y43(0.48)  LDD0268  [2]

References

1 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
2 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
3 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
4 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060