Details of the Target

General Information of Target

Target ID LDTP16955
Target Name Cysteine-rich secretory protein 2 (CRISP2)
Gene Name CRISP2
Gene ID 7180
Synonyms
GAPDL5; TPX1; Cysteine-rich secretory protein 2; CRISP-2; Cancer/testis antigen 36; CT36; Testis-specific protein TPX-1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDSVAFEDVAVNFTQEEWALLGPSQKSLYRNVMQETIRNLDCIEMKWEDQNIGDQCQNAK
RNLRSHTCEIKDDSQCGETFGQIPDSIVNKNTPRVNPCDSGECGEVVLGHSSLNCNIRVD
TGHKSCEHQEYGEKPYTHKQRGKAISHQHSFQTHERPPTGKKPFDCKECAKTFSSLGNLR
RHMAAHHGDGPYKCKLCGKAFVWPSLFHLHERTHTGEKPYECKQCSKAFPFYSSYLRHER
IHTGEKAYECKQCSKAFPDYSTYLRHERTHTGEKPYKCTQCGKAFSCYYYTRLHERTHTG
EQPYACKQCGKTFYHHTSFRRHMIRHTGDGPHKCKICGKGFDCPSSVRNHETTHTGEKPY
ECKQCGKVLSHSSSFRSHMITHTGDGPQKCKICGKAFGCPSLFQRHERTHTGEKPYQCKQ
CGKAFSLAGSLRRHEATHTGVKPYKCQCGKAFSDLSSFQNHETTHTGEKPYECKECGKAF
SCFKYLSQHKRTHTVEKPYECKTCRKAFSHFSNLKVHERIHSGEKPYECKECGKAFSWLT
CLLRHERIHTGEKPYECLQCGKAFTRSRFLRGHEKTHTGEKLYECKECGKALSSLRSLHR
HKRTHWKDTL
Target Bioclass
Other
Family
CRISP family
Subcellular location
Secreted
Function May regulate some ion channels' activity and therebye regulate calcium fluxes during sperm capacitation.
Uniprot ID
P16562
Ensemble ID
ENST00000339139.5
HGNC ID
HGNC:12024

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
COLO678 Insertion: p.A55PfsTer8 .
LS123 Insertion: p.A55PfsTer5 .
MEWO Insertion: p.A55PfsTer8 .
SKMEL5 SNV: p.N42I .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IA-alkyne
 Probe Info  		N.A.  LDD0161  [1]

References

1 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060