Details of the Target

General Information of Target

Target ID LDTP16950
Target Name Pregnancy-specific beta-1-glycoprotein 2 (PSG2)
Gene Name PSG2
Gene ID 5670
Synonyms
PSBG2; Pregnancy-specific beta-1-glycoprotein 2; PS-beta-G-2; PSBG-2; Pregnancy-specific glycoprotein 2; Pregnancy-specific beta-1 glycoprotein E; PS-beta-E
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAALGDIQESPSVPSPVSLSSPGTPGTQHHEPQLHLHGHQHGSPGSSPKVLSQPSDLDLQ
DVEEVEIGRDTFWPDSEPKPEQAPRSPGSQAPDEGAGGALRSLLRSLPRRARCSAGFGPE
SSAERPAGQPPGAVPCAQPRGAWRVTLVQQAAAGPEGAPERAAELGVNFGRSRQGSARGA
KPHRCEACGKSFKYNSLLLKHQRIHTGEKPYACHECGKRFRGWSGFIQHHRIHTGEKPYE
CGQCGRAFSHSSHFTQHLRIHNGEKPYKCGECGQAFSQSSNLVRHQRLHTGEKPYACSQC
GKAFIWSSVLIEHQRIHTGEKPYECSDCGKAFRGRSHFFRHLRTHTGEKPFACGACGKAF
GQSSQLIQHQRVHYRE
Target Bioclass
Immunoglobulin
Family
Immunoglobulin superfamily, CEA family
Subcellular location
Secreted
Uniprot ID
P11465
Ensemble ID
ENST00000406487.6
HGNC ID
HGNC:9519

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C394(1.67)  LDD3485  [1]
IA-alkyne
 Probe Info  		C1461(0.00); C1957(0.00); C212(0.00); C195(0.00)  LDD0161  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 CAL-120 C95(3.59)  LDD2284  [1]
 LDCM0023  KB03 CAL-120 C95(5.19)  LDD2701  [1]
 LDCM0024  KB05 UM-UC-3 C394(1.67)  LDD3485  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060