Details of the Target

General Information of Target

Target ID LDTP16945
Target Name Zinc finger TRAF-type-containing protein 1 (ZFTRAF1)
Gene Name ZFTRAF1
Gene ID 157542
Synonyms
CYHR1; KIAA0496; Zinc finger TRAF-type-containing protein 1; Cysteine and histidine-rich protein 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MLVCVLLYSFRLFGIQGEAQLTESGGDLVHLEGPLRLSCAASWFTFSIYEIHWVCQASGK
GLEWVAVIWRGESHQYNADYVRGRLTTSRDNTKYMLYMQMISLRTQNMAAFNCAG
Target Bioclass
Other
Family
ZFTRAF1 family
Subcellular location
Cytoplasm
Uniprot ID
P0DTL6
Ensemble ID
ENST00000530374.6
HGNC ID
HGNC:17806

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C299(1.71)  LDD3310  [1]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [2]
IPM
 Probe Info  		N.A.  LDD0025  [3]
NAIA_5
 Probe Info  		N.A.  LDD2224  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 22RV1 C299(1.79)  LDD2243  [1]
 LDCM0023  KB03 22RV1 C299(2.88)  LDD2660  [1]
 LDCM0024  KB05 COLO792 C299(1.71)  LDD3310  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
3 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
4 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264